{"id":"W3002596640","doi":"10.1084/jem.20190723","title":"Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft; Canada Research Chairs; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Platelet; Sialic acid; Macrophage; Asialoglycoprotein receptor; Kupffer cell; Cell biology; Chemistry; Platelet activation; P-selectin; Population; Lectin; Immunology; Biology; Hepatocyte; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002578549,0.0002556771,0.0002558951,0.0002145424,0.0001632259,0.0003603644,0.0002329872,0.0003656177,0.001435122],"category_scores_gemma":[0.0002347845,0.0001387025,0.0002751524,0.00008862449,0.0002916944,0.0003159675,0.0003261623,0.0005905424,0.0006329025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003847564,"about_ca_system_score_gemma":0.0003710908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007162669,"about_ca_topic_score_gemma":0.0007479984,"domain_scores_codex":[0.9997548,0.00005164497,0.00002087832,0.00003537025,0.00004999309,0.00008731998],"domain_scores_gemma":[0.9997696,0.00001648782,0.0000532376,0.00002002327,0.0000411309,0.0000994376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001108187,0.00001579834,0.0003556184,0.00002849986,0.000003425912,0.00009163457,0.00002009739,0.0000157858,0.9983906,0.0001745214,0.00005787185,0.0007354423],"study_design_scores_gemma":[0.00007291395,0.0007282003,0.0336215,0.00003167698,0.00004252951,0.001699487,0.0001991095,0.001872559,0.9510599,0.0003728396,0.01027918,0.00002018499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875209,0.004267801,0.005065249,0.000522133,0.00008328774,0.00003896317,0.0002117796,0.0001858508,0.002104098],"genre_scores_gemma":[0.9912099,0.001030528,0.003565574,0.0002146686,0.00003186136,0.00004554034,0.0002860146,0.00003406286,0.003581867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435122,"threshold_uncertainty_score":0.004800975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04003939714285448,"score_gpt":0.3496505082237674,"score_spread":0.3096111110809129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}