{"id":"W3002596640","doi":"10.1084/jem.20190723","title":"Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft; Canada Research Chairs; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Platelet; Sialic acid; Macrophage; Asialoglycoprotein receptor; Kupffer cell; Cell biology; Chemistry; Platelet activation; P-selectin; Population; Lectin; Immunology; Biology; Hepatocyte; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002651242,0.0001995427,0.0005705802,0.00007197856,0.0001126018,0.000009442423,0.0001602955,0.00006178989,0.0009450893],"category_scores_gemma":[0.000220988,0.0001119925,0.0001321195,0.0001591029,0.0001279233,0.00006808295,0.00003987141,0.000280859,0.00005534291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007072859,"about_ca_system_score_gemma":0.00004102585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001648558,"about_ca_topic_score_gemma":4.531645e-7,"domain_scores_codex":[0.9986138,0.00005764638,0.0004647276,0.0001470546,0.000428265,0.0002885215],"domain_scores_gemma":[0.9988313,0.0002739051,0.000119785,0.0001469538,0.00009846419,0.0005295913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007748558,0.0004092607,0.00007651811,0.00004029223,0.0002088398,0.000906395,0.008221108,0.000001981016,0.8928443,0.00003000263,0.08874415,0.0007686265],"study_design_scores_gemma":[0.01248437,0.02042801,0.0005940678,0.0003127071,0.0004513469,0.001462888,0.006333436,0.0001088746,0.9400408,0.00007028036,0.01752755,0.000185633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527446,0.00346198,0.0003991832,0.04161439,0.0003861426,0.0005442892,0.000007876264,0.00001564771,0.0008258998],"genre_scores_gemma":[0.9774365,0.00009221552,0.0008005792,0.02083632,0.0005133625,0.0000061254,0.000002741468,0.00003583872,0.0002762525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0712166,"threshold_uncertainty_score":0.9999682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04003939714285448,"score_gpt":0.3496505082237674,"score_spread":0.3096111110809129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}