{"id":"W3002673995","doi":"10.3390/mi11020227","title":"An Engineered Infected Epidermis Model for In Vitro Study of the Skin’s Pro-Inflammatory Response","year":2020,"lang":"en","type":"article","venue":"Micromachines","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Victoria","keywords":"Epidermis (zoology); Filaggrin; Skin equivalent; Barrier function; Tumor necrosis factor alpha; In vitro; Keratinocyte; Penetration (warfare); Human skin; Chemistry; Immunology; Cell biology; Biomedical engineering; Medicine; Biology; Biochemistry; Anatomy; Atopic dermatitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002234801,0.000396712,0.0002253426,0.0002584952,0.0001373317,0.0002820491,0.0001913229,0.0003851982,0.001134783],"category_scores_gemma":[0.00009193987,0.0001886337,0.0003490514,0.0001861908,0.0001618302,0.0003021369,0.0002008879,0.0007270783,0.0003655689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001440846,"about_ca_system_score_gemma":0.0001511422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002397966,"about_ca_topic_score_gemma":0.0004045347,"domain_scores_codex":[0.9997972,0.00002360388,0.00002278761,0.00004802983,0.00008065876,0.00002778815],"domain_scores_gemma":[0.9998752,0.00002227243,0.0000310001,0.00002895706,0.00002201316,0.00002058182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002644179,0.00003851061,0.00007774455,0.00002405964,0.000002380726,0.00005695968,0.00001530158,0.00005452205,0.9992276,0.00006431845,0.00001274759,0.0003994048],"study_design_scores_gemma":[0.000008822327,0.0005955668,0.002331885,0.000010203,0.00002060623,0.0004663636,0.0000486236,0.001800076,0.9931729,0.00006229024,0.001474061,0.000008457472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633685,0.001545178,0.03110589,0.00007006428,0.0001497825,0.0001638207,0.0005669419,0.0001657442,0.002864088],"genre_scores_gemma":[0.9624015,0.001354177,0.0312399,0.00009192865,0.00002053617,0.0002140843,0.0006480489,0.00003642795,0.003993448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134783,"threshold_uncertainty_score":0.00379622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384150271130872,"score_gpt":0.2888562500934898,"score_spread":0.2650147473821811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}