{"id":"W3002753079","doi":"10.1016/j.bone.2020.115250","title":"Finite element analysis of bone strength in osteogenesis imperfecta","year":2020,"lang":"en","type":"review","venue":"Bone","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Montreal Children's Hospital","funders":"National Institutes of Health; Mereo BioPharma; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Shriners Hospitals for Children","keywords":"Osteogenesis imperfecta; Sclerostin; Bone tissue; Finite element method; Bone structure; Osteoporosis; Medicine; Biomedical engineering; Chemistry; Structural engineering; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002822098,0.0003096219,0.001677637,0.0005590193,0.00002052998,0.00001130307,0.0002482182,0.0002554299,0.0002831095],"category_scores_gemma":[0.0003841972,0.0002959876,0.0007498187,0.001477874,0.0000500128,0.00000129149,0.0003391811,0.000172442,0.00002279174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004779213,"about_ca_system_score_gemma":0.0002739535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215592,"about_ca_topic_score_gemma":0.0007381546,"domain_scores_codex":[0.9979312,0.0002496171,0.0006569143,0.0006173963,0.0002441208,0.0003007072],"domain_scores_gemma":[0.9989116,0.00008432973,0.0002565383,0.0005751955,0.00008262463,0.00008976604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003672163,0.0001448727,0.0002042645,0.00267024,0.002290915,0.00003840793,0.00003112371,0.00002458179,0.001144913,0.00001281503,0.0002251785,0.993176],"study_design_scores_gemma":[0.0003048852,0.0002312288,0.00008907801,0.0003986064,0.001810065,0.00000245785,0.000034254,0.00008586359,0.000458398,0.000001667304,0.9962708,0.0003127457],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001014868,0.9976199,0.00007272623,0.00002757138,0.0000215136,0.0005284643,0.000419199,0.000004207312,0.0002915311],"genre_scores_gemma":[0.003622761,0.9940096,0.0000639468,0.00001189314,0.00005300226,0.0001276456,0.001751791,0.00004254149,0.0003167933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9960456,"threshold_uncertainty_score":0.9999492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03138028344286165,"score_gpt":0.3475398357510164,"score_spread":0.3161595523081548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}