{"id":"W3002798034","doi":"10.1111/acel.13103","title":"Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function","year":2020,"lang":"en","type":"article","venue":"Aging Cell","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Extracellular vesicles; Senescence; Extracellular vesicle; Function (biology); Extracellular; Cellular senescence; Cell biology; Microvesicles; Genetics; Phenotype; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003718068,0.0002789831,0.0003326366,0.0003030791,0.0001252601,0.0004179332,0.0001165674,0.0003006969,0.0007983598],"category_scores_gemma":[0.000247347,0.0001180532,0.0003436563,0.0001354851,0.00020292,0.0003432277,0.0003093866,0.0004069163,0.0002599358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851345,"about_ca_system_score_gemma":0.0001207764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001958791,"about_ca_topic_score_gemma":0.0001429227,"domain_scores_codex":[0.9998466,0.00002953703,0.00002336777,0.00003625156,0.00003276968,0.0000314418],"domain_scores_gemma":[0.9997699,0.00002341058,0.00008742512,0.00002920354,0.00004842331,0.00004162909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002320153,0.00002759609,0.002638124,0.00004825183,0.00001362941,0.0001264593,0.00004350617,0.00006137139,0.9937413,0.0001967842,0.00007087306,0.002799973],"study_design_scores_gemma":[0.00002322952,0.0009469992,0.1303732,0.00003326168,0.00007705869,0.001613613,0.0001910071,0.001975612,0.8561152,0.0008610365,0.007770205,0.00001947623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865827,0.006807588,0.005089491,0.0001141741,0.00007032252,0.00001742063,0.000331423,0.00005395611,0.0009330372],"genre_scores_gemma":[0.9955559,0.00170888,0.0009881447,0.00008707457,0.00002969113,0.00002358396,0.000210602,0.00001334152,0.001382794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007983598,"threshold_uncertainty_score":0.002670825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074395719877707,"score_gpt":0.2189439142419816,"score_spread":0.2081999570432045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}