{"id":"W3002857424","doi":"10.1111/febs.15220","title":"New regulatory mechanism‐based inhibitors of aspartate transcarbamoylase for potential anticancer drug development","year":2020,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aspartate carbamoyltransferase; Pyrimidine metabolism; Allosteric regulation; Biochemistry; Active site; Biology; Drug discovery; Enzyme; Purine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433785,0.0005971768,0.0006910204,0.0003488947,0.0001767138,0.0004988974,0.0006630411,0.0003597359,0.001998592],"category_scores_gemma":[0.00009843168,0.0002517517,0.0004114698,0.0002756612,0.0002058476,0.0004702931,0.0003258497,0.0008545198,0.0005538453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532702,"about_ca_system_score_gemma":0.000384465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004412346,"about_ca_topic_score_gemma":0.001392448,"domain_scores_codex":[0.999922,0.0000113874,0.000005947916,0.00001907916,0.0000224264,0.00001917308],"domain_scores_gemma":[0.9999664,0.000004343576,0.000008389407,0.000003543771,0.00000716809,0.00001024355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008347845,0.0008082988,0.0006182562,0.0006839262,0.0001001158,0.0004656314,0.00006197303,0.00364803,0.9150972,0.004126625,0.002166516,0.07138869],"study_design_scores_gemma":[0.002686898,0.008284405,0.004324043,0.0001594384,0.0005101314,0.003156779,0.00007358682,0.02141714,0.8412933,0.002270035,0.1156914,0.0001328629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8170891,0.08933797,0.05903888,0.001772405,0.0005918996,0.001187905,0.002607586,0.001719955,0.02665423],"genre_scores_gemma":[0.9246836,0.0341334,0.02785007,0.0007654065,0.00007573717,0.0003790793,0.003107957,0.00006560033,0.00893922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001998592,"threshold_uncertainty_score":0.006685972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382753141152873,"score_gpt":0.2512631577910664,"score_spread":0.2374356263795377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}