{"id":"W3002857424","doi":"10.1111/febs.15220","title":"New regulatory mechanism‐based inhibitors of aspartate transcarbamoylase for potential anticancer drug development","year":2020,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aspartate carbamoyltransferase; Pyrimidine metabolism; Allosteric regulation; Biochemistry; Active site; Biology; Drug discovery; Enzyme; Purine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918891,0.000133169,0.0001607257,0.00003282321,0.00008117943,0.00002269881,0.0001958563,0.00009886571,0.00006273368],"category_scores_gemma":[0.00003748427,0.0001190936,0.0002018415,0.00007190766,0.00004220666,0.000003637595,0.00004220659,0.0001481859,0.000002792008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001300783,"about_ca_system_score_gemma":0.0005460073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003359159,"about_ca_topic_score_gemma":0.000002094373,"domain_scores_codex":[0.9988794,0.00003964592,0.0002941772,0.0002313892,0.0002838116,0.0002715965],"domain_scores_gemma":[0.999287,0.000005427897,0.0000996512,0.0001112669,0.0001364736,0.0003601793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004899722,0.00003531026,0.00004225824,0.0000507186,0.00007485069,0.000008054666,0.0000596986,0.00007463157,0.983303,0.00002889772,0.01158173,0.004250868],"study_design_scores_gemma":[0.001436493,0.0002318469,0.0000872519,0.00002597248,0.00002496632,0.00001248806,0.00002390168,0.0001967221,0.9803029,0.0001126356,0.01740005,0.0001448252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8279037,0.0007578861,0.168729,0.002118581,0.0001730793,0.0002410189,0.00001665466,0.000007796899,0.00005224939],"genre_scores_gemma":[0.9881201,0.00004608533,0.01052471,0.0005021725,0.000517756,0.000007678492,0.00003715235,0.00002527217,0.0002190941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1602164,"threshold_uncertainty_score":0.4856496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382753141152873,"score_gpt":0.2512631577910664,"score_spread":0.2374356263795377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}