{"id":"W3003014250","doi":"10.3389/fcell.2019.00367","title":"Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Senescence; Ageing; Biology; Phenotype; Carcinogenesis; Pleiotropy; Inflammation; Progeria; Cell biology; Mechanism (biology); Immune system; Transgene; Immunology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005016161,0.0008131446,0.001079211,0.001740023,0.0002663433,0.0008092522,0.0006749713,0.0009351568,0.003189704],"category_scores_gemma":[0.0004321894,0.0002215133,0.0003899316,0.001098513,0.00050945,0.00115047,0.0006765069,0.002407802,0.001770659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004316008,"about_ca_system_score_gemma":0.0006783288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004308757,"about_ca_topic_score_gemma":0.001020775,"domain_scores_codex":[0.9998888,0.00001949459,0.00001683037,0.00002136692,0.00004007964,0.000013476],"domain_scores_gemma":[0.9998164,0.00007812618,0.00002749911,0.000006677596,0.00004490462,0.00002638523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001188112,0.00009047487,0.0001336956,0.01250616,0.00008823744,0.0001683868,0.00006364032,0.0002647049,0.004386848,0.0071172,0.02285454,0.9522074],"study_design_scores_gemma":[0.00003289633,0.0001577815,0.0006702768,0.002280056,0.00008323682,0.0009115697,0.00004674077,0.00007143065,0.001214848,0.003038515,0.9914745,0.00001817866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001706386,0.9980934,0.0001795208,0.0002989436,0.0002613771,0.000006402577,0.00002371753,0.00001493179,0.000951019],"genre_scores_gemma":[0.001080904,0.9973903,0.0002602752,0.0003182688,0.0001900198,0.00001080503,0.00005526301,0.000002419938,0.0006917976],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003189704,"threshold_uncertainty_score":0.01067066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03405338077810329,"score_gpt":0.2784140504668217,"score_spread":0.2443606696887184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}