{"id":"W3003014418","doi":"10.1016/j.bbmt.2019.12.575","title":"Targeted Conditioning with Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Leads to High Rates of Allogeneic Transplantation and Successful Engraftment in Older Patients with Active, Relapsed or Refractory (rel/ref) AML after Failure of Chemotherapy and Targeted Agents: Preliminary Midpoint Results from the Prospective, Randomized Phase 3 Sierra Trial","year":2020,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Venetoclax; Salvage therapy; Internal medicine; Refractory (planetary science); Transplantation; Oncology; Randomization; Clinical trial; Randomized controlled trial; Surgery; Chemotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294729,0.0002326521,0.0006972432,0.0001088702,0.00005254501,0.000006294186,0.00004346047,0.000158792,0.00002410536],"category_scores_gemma":[0.00004420846,0.0001325846,0.00004787914,0.0001634612,0.0003577064,0.0001089013,0.000005017256,0.0001290807,9.171464e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009064026,"about_ca_system_score_gemma":0.00007145951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845921,"about_ca_topic_score_gemma":0.00006334354,"domain_scores_codex":[0.9985346,0.0002201249,0.0005619401,0.0003808987,0.0001504598,0.0001520274],"domain_scores_gemma":[0.9990126,0.0003342244,0.0003438428,0.00009474216,0.0001127206,0.0001018221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8144171,0.0009323788,0.03115808,0.0003622765,0.0006645401,0.00003501188,0.005422337,0.000009645314,0.1466706,0.000004760865,0.000005951772,0.0003173364],"study_design_scores_gemma":[0.5325754,0.00616943,0.3157154,0.0005218527,0.001497047,0.000007723246,0.0002310711,0.00003439241,0.1430938,0.00001018808,0.000001982841,0.0001416267],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940947,0.0009792178,0.0001243058,0.0004718813,0.00002459978,0.002310553,0.001973425,0.00001800578,0.000003272678],"genre_scores_gemma":[0.9950519,0.00196667,0.000567427,0.0001267327,0.00002072291,0.0001122323,0.002130746,0.00002078009,0.000002789048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2845573,"threshold_uncertainty_score":0.5406643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007453411149889952,"score_gpt":0.2449032930180531,"score_spread":0.2374498818681632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}