{"id":"W3003014418","doi":"10.1016/j.bbmt.2019.12.575","title":"Targeted Conditioning with Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Leads to High Rates of Allogeneic Transplantation and Successful Engraftment in Older Patients with Active, Relapsed or Refractory (rel/ref) AML after Failure of Chemotherapy and Targeted Agents: Preliminary Midpoint Results from the Prospective, Randomized Phase 3 Sierra Trial","year":2020,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Venetoclax; Salvage therapy; Internal medicine; Refractory (planetary science); Transplantation; Oncology; Randomization; Clinical trial; Randomized controlled trial; Surgery; Chemotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001713055,0.0005252868,0.0008215295,0.0002131579,0.0002075112,0.0006259319,0.0003778252,0.0003702629,0.001663424],"category_scores_gemma":[0.0008270261,0.0002219218,0.0007732353,0.0001876,0.0004505886,0.0004001721,0.0002744437,0.001294719,0.0003154222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798724,"about_ca_system_score_gemma":0.0004766471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00046067,"about_ca_topic_score_gemma":0.001574919,"domain_scores_codex":[0.9995732,0.0002268119,0.00003334149,0.00005713565,0.00004747299,0.00006209367],"domain_scores_gemma":[0.9993061,0.0001643263,0.0001651026,0.0000677415,0.00002505052,0.0002716799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.649204,0.0414399,0.02282484,0.0007268323,0.001797277,0.0002202546,0.0003391227,0.002485412,0.06553951,0.0004609366,0.007953208,0.2070086],"study_design_scores_gemma":[0.4225864,0.4847057,0.07119227,0.0001079177,0.001847959,0.0005641787,0.00009454646,0.002052573,0.01007258,0.0004614931,0.006256585,0.00005769051],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950494,0.002513858,0.0003723602,0.0003227894,0.00007193914,0.000298969,0.0002842477,0.00005191801,0.001034538],"genre_scores_gemma":[0.9956682,0.001418569,0.0006989337,0.0005603114,0.0001282885,0.0002156023,0.0006893756,0.00001461214,0.0006059931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713055,"threshold_uncertainty_score":0.009059608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007453411149889952,"score_gpt":0.2449032930180531,"score_spread":0.2374498818681632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}