{"id":"W3003078574","doi":"10.1093/nar/gkz1220","title":"Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Albert-Ludwigs-Universität Freiburg; Deutscher Akademischer Austauschdienst","keywords":"Biology; Gene; Biochemistry; Mutant; Regulation of gene expression; Guanosine; Regulator gene; Second messenger system; Gene expression; Phosphodiesterase; Genetics; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009198231,0.0003668584,0.0003427454,0.0002198792,0.0001241423,0.0003989648,0.0001120961,0.0001730252,0.0004640051],"category_scores_gemma":[0.0001076685,0.0001186064,0.0001363575,0.0001823894,0.0001965286,0.0001557594,0.0002220506,0.0003434283,0.0002407179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075773,"about_ca_system_score_gemma":0.0002130468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006290106,"about_ca_topic_score_gemma":0.0005622421,"domain_scores_codex":[0.9999059,0.00001614499,0.00001055559,0.00003128504,0.00002246305,0.00001360158],"domain_scores_gemma":[0.9998655,0.00002320272,0.00003440461,0.00001562059,0.0000160021,0.00004515385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002952478,0.000002992095,0.0001400914,0.000009193979,6.251666e-7,0.00001545883,0.000003392914,0.00001918975,0.9994311,0.0000169352,0.000003405193,0.000328076],"study_design_scores_gemma":[0.00001814323,0.0001641714,0.01958543,0.000006663168,0.00001285929,0.0001943766,0.00004484933,0.001093328,0.9774066,0.00009124359,0.001374572,0.000007803283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946963,0.001557661,0.001965754,0.00005641755,0.00001353541,0.0000163477,0.0003752605,0.0001033256,0.001215446],"genre_scores_gemma":[0.9963753,0.0005146225,0.001533557,0.00002978877,0.000006503039,0.00001870574,0.0004951539,0.00002304765,0.001003315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006290106,"threshold_uncertainty_score":0.002231598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03301923092632045,"score_gpt":0.3142633979743896,"score_spread":0.2812441670480691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}