{"id":"W3003130163","doi":"10.1002/bit.27276","title":"High‐level heterologous production of propionate in engineered <i>Escherichia coli</i>","year":2020,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glyoxylate cycle; Citric acid cycle; Biochemistry; Propionate; Flux (metallurgy); Chemistry; SDHA; Operon; Metabolic pathway; Tricarboxylic acid; Escherichia coli; Metabolism; Biology; Succinate dehydrogenase; Enzyme; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424448,0.0005317235,0.000309739,0.0001501818,0.0001089599,0.0003909993,0.0003020013,0.0002419695,0.0003941145],"category_scores_gemma":[0.0001219015,0.0001505143,0.0002718051,0.0002427642,0.0001817703,0.0001736008,0.0002939723,0.000528661,0.0002811012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359178,"about_ca_system_score_gemma":0.0003000855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001484394,"about_ca_topic_score_gemma":0.001372354,"domain_scores_codex":[0.9998572,0.00002108028,0.0000162187,0.0000294257,0.00004005342,0.00003597779],"domain_scores_gemma":[0.9998926,0.00001740187,0.0000324267,0.0000162749,0.00001715836,0.00002407985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002433944,0.00001822947,0.000103671,0.00001496986,0.000003253217,0.00003011304,0.00000780328,0.00008998329,0.9991868,0.00007373718,0.00001436203,0.0004329039],"study_design_scores_gemma":[0.000005069271,0.00006480905,0.0007036495,0.000002083979,0.000008971082,0.00005515842,0.00001722531,0.0009967689,0.9974689,0.00001901037,0.0006545748,0.000003799968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893455,0.0002282776,0.007843466,0.0001014838,0.00003680562,0.00004386364,0.0004953982,0.0001817454,0.00172339],"genre_scores_gemma":[0.986408,0.0003037232,0.009978969,0.00005987135,0.000009740844,0.00003100497,0.0008766121,0.00009342507,0.002238708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484394,"threshold_uncertainty_score":0.002951503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009504280808263332,"score_gpt":0.1875491362816377,"score_spread":0.1780448554733744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}