{"id":"W3003130163","doi":"10.1002/bit.27276","title":"High‐level heterologous production of propionate in engineered <i>Escherichia coli</i>","year":2020,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glyoxylate cycle; Citric acid cycle; Biochemistry; Propionate; Flux (metallurgy); Chemistry; SDHA; Operon; Metabolic pathway; Tricarboxylic acid; Escherichia coli; Metabolism; Biology; Succinate dehydrogenase; Enzyme; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008578838,0.0001460317,0.0001854191,0.00009016679,0.00001776416,0.000003724501,0.00009662713,0.0002928201,0.000001276892],"category_scores_gemma":[0.00009232356,0.0001408251,0.00002857838,0.000247604,0.00007078638,0.000004810463,0.00006425481,0.0001605259,0.00000106018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005437266,"about_ca_system_score_gemma":0.00001138668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001128264,"about_ca_topic_score_gemma":0.000004191404,"domain_scores_codex":[0.9992417,0.00001098631,0.0002018046,0.0003240134,0.00004364737,0.0001779011],"domain_scores_gemma":[0.9997408,0.000001302844,0.0000427086,0.0001523534,0.00002400313,0.00003882454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004911471,0.00002066545,0.0001579585,0.00008354588,0.00002666242,0.000001401892,0.00002436834,0.002386244,0.9954159,0.000189391,0.00005426197,0.0015905],"study_design_scores_gemma":[0.0002854645,0.0002147147,0.001920146,0.00001675604,0.0000100773,0.00001498705,0.00001499979,0.0003851631,0.9930701,0.000005656029,0.00391265,0.0001492929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924877,0.001043144,0.004081888,0.001826776,0.0003086803,0.0001686621,0.00001021423,0.00007029644,0.000002676219],"genre_scores_gemma":[0.9946136,0.0004952896,0.004582372,0.00006060547,0.0001745925,0.00001130424,0.00002371092,0.00001623279,0.00002231487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003858387,"threshold_uncertainty_score":0.5742682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009504280808263332,"score_gpt":0.1875491362816377,"score_spread":0.1780448554733744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}