{"id":"W3003197239","doi":"10.3389/fonc.2020.00066","title":"Commentary: Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial","year":2020,"lang":"en","type":"letter","venue":"Frontiers in Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Temozolomide; Lomustine; Medicine; Glioblastoma; Oncology; Internal medicine; Open label; O-6-methylguanine-DNA methyltransferase; Bevacizumab; Dacarbazine; Progression-free survival; Randomized controlled trial; Chemotherapy; Cancer research; Methylation; Methyltransferase; Vincristine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006379494,0.001257509,0.003846033,0.001041043,0.0001662899,0.0001548991,0.0007622764,0.001221855,0.0001469869],"category_scores_gemma":[0.0002212641,0.0008999537,0.0001955861,0.00110091,0.0004252801,0.0003387705,0.0001599627,0.002441332,0.00000976581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002763948,"about_ca_system_score_gemma":0.0009157601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003703412,"about_ca_topic_score_gemma":0.000375414,"domain_scores_codex":[0.9932622,0.001625743,0.001446009,0.001564542,0.000987911,0.001113595],"domain_scores_gemma":[0.9963207,0.001034051,0.001112132,0.0008702967,0.0003636326,0.0002991922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5394659,0.007543492,0.007570941,0.00004115325,0.001653318,0.004543941,0.0003653047,0.000004159904,0.00001338503,0.000001059696,0.4099273,0.02887003],"study_design_scores_gemma":[0.6741832,0.1359782,0.0004054712,0.0002905948,0.0004433924,0.000008517165,0.00008670576,0.00009290493,0.0003780139,0.00004109928,0.1874569,0.0006349648],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7260148,0.0007287042,0.00008583476,0.2483764,0.00224187,0.02192724,0.0002963786,0.0001123235,0.0002164228],"genre_scores_gemma":[0.2233592,0.003380091,0.01978187,0.7145504,0.003018543,0.01827494,0.01619725,0.001242523,0.0001952806],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5026556,"threshold_uncertainty_score":0.99986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02732472459292446,"score_gpt":0.3146874924040877,"score_spread":0.2873627678111633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}