{"id":"W3003215342","doi":"10.1038/s41375-019-0702-7","title":"In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees","year":2020,"lang":"en","type":"letter","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Pedigree chart; Exome sequencing; Multiplex; Exome; Genetics; Leukemia; Hairy cell leukemia; Biology; Medicine; Oncology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005532022,0.0005479008,0.0003823422,0.0006043214,0.001410126,0.0007748861,0.000537178,0.004884221,0.002111632],"category_scores_gemma":[0.003251372,0.0002682948,0.0002978133,0.0004436771,0.0004993536,0.0006568177,0.0004836904,0.0020837,0.0005269792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007038618,"about_ca_system_score_gemma":0.0005261302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003259182,"about_ca_topic_score_gemma":0.004540822,"domain_scores_codex":[0.9996345,0.0001044706,0.00004975674,0.00007267827,0.00007213168,0.00006641584],"domain_scores_gemma":[0.9985244,0.0008648531,0.00008971941,0.00004388441,0.0001462634,0.0003309072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006970893,0.0001445419,0.08268418,0.000108417,0.00009785445,0.8046626,0.00217814,0.0005488894,0.01488861,0.001800843,0.06017241,0.03201642],"study_design_scores_gemma":[0.0002432758,0.0004177848,0.05706704,0.0001985205,0.0002332767,0.8617771,0.002706563,0.004674247,0.005368391,0.006183201,0.06106501,0.00006550122],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6904635,0.004241505,0.002712516,0.2859825,0.002476278,0.0001091698,0.0007282443,0.0001421781,0.01314404],"genre_scores_gemma":[0.9062673,0.002430153,0.00298432,0.07499521,0.004758564,0.00004511421,0.0002330842,0.00004935284,0.00823697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004884221,"threshold_uncertainty_score":0.007064164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04943081365974037,"score_gpt":0.2921088069204417,"score_spread":0.2426779932607013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}