{"id":"W3003289036","doi":"10.1016/j.tips.2019.12.008","title":"Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies","year":2020,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Heart, Lung, and Blood Institute; U.S. Department of Defense; American Lung Association; Boehringer Ingelheim; Canadian Pulmonary Fibrosis Foundation","keywords":"G protein-coupled receptor; Idiopathic pulmonary fibrosis; Pulmonary fibrosis; Signal transduction; Fibrosis; Biology; Bioinformatics; Cancer research; Cell biology; Medicine; Immunology; Lung; Pathology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001061277,0.0005839883,0.00210816,0.0004103828,0.0003486424,0.00008939332,0.0006147806,0.0003635589,0.0007548286],"category_scores_gemma":[0.0001509455,0.0003751745,0.00109026,0.001538311,0.0005203741,0.0001609305,0.0001863934,0.0006756238,0.00002820395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096806,"about_ca_system_score_gemma":0.0003156804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001058698,"about_ca_topic_score_gemma":2.800025e-7,"domain_scores_codex":[0.9963111,0.0003065803,0.0009854031,0.001128968,0.0004978242,0.0007701083],"domain_scores_gemma":[0.9987313,0.0004125201,0.0003580996,0.0001165495,0.00005351968,0.000328051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005164293,0.0002923314,0.00001863784,0.005259464,0.0001134145,0.0003454168,0.00006231799,0.00001187994,0.0005873157,0.000167524,0.0008708289,0.9917544],"study_design_scores_gemma":[0.0004807936,0.003804275,0.00001126236,0.01017927,0.001766271,0.00009336785,0.0001189006,0.001865985,0.00002394071,0.0002250326,0.9807333,0.000697595],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006711917,0.9961101,0.0000393573,0.0006770137,0.0005266565,0.0008657378,0.0001472252,0.0001360829,0.001430704],"genre_scores_gemma":[0.01541155,0.9809409,0.0009808133,0.0003654457,0.001422735,0.0005330921,0.0001263188,0.00003975153,0.0001793693],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9910569,"threshold_uncertainty_score":0.99987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068691790290104,"score_gpt":0.4105404491932342,"score_spread":0.3036712701642238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}