{"id":"W3003474239","doi":"10.1089/hum.2019.211","title":"Optimized Pre-Clinical Grade Production of Two Novel Lentiviral Vector Pseudotypes for Lung Gene Delivery","year":2020,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Infectious Diseases and Mycology","field":"Veterinary","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Guelph","funders":"","keywords":"Genetic enhancement; Virology; Vesicular stomatitis virus; Viral vector; Gene delivery; Biology; Transduction (biophysics); Retrovirus; Tropism; Transgene; Molecular biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093033,0.0001790744,0.0003718382,0.00004737882,0.0001404284,0.00001551541,0.0001598995,0.00008998519,0.000280725],"category_scores_gemma":[0.00003159584,0.0001694045,0.0003089889,0.00008043549,0.00008973386,0.00008538069,0.00004316114,0.0001111342,0.00000960838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002776125,"about_ca_system_score_gemma":0.00005627119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005036397,"about_ca_topic_score_gemma":0.000005377457,"domain_scores_codex":[0.9986655,0.0001217848,0.0004332958,0.0004205336,0.0001122889,0.000246613],"domain_scores_gemma":[0.9992781,0.0000628416,0.000203872,0.000256301,0.0001160788,0.00008279095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005846416,0.0009481215,0.001775207,0.00006872298,0.0004763785,0.000009016086,0.0006150341,0.0004806345,0.9845484,0.0004342113,0.003722728,0.001075094],"study_design_scores_gemma":[0.09214132,0.05554692,0.2665568,0.0001216839,0.001621526,0.0004073693,0.0002232838,0.02648515,0.5319079,0.002790668,0.018699,0.003498303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943051,0.0007457833,0.002789174,0.00020508,0.0007002389,0.001007921,0.00004994061,0.00011542,0.00008139492],"genre_scores_gemma":[0.9931197,0.0002661268,0.004212902,0.0004656735,0.001499165,0.0001274383,0.00008214136,0.00004983614,0.0001770605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4526405,"threshold_uncertainty_score":0.6908114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1414680239758603,"score_gpt":0.3992346562041557,"score_spread":0.2577666322282954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}