{"id":"W3003551095","doi":"10.1111/xen.12570","title":"Epigenetic biomarkers indicate islet cell death in xenotransplantation","year":2020,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Juvenile Diabetes Research Foundation United Kingdom; Foundation for the National Institutes of Health","keywords":"Xenotransplantation; Epigenetics; Biology; Islet; DNA methylation; Biomarker; Transplantation; CpG site; Molecular biology; Cancer research; Genetics; Gene; Medicine; Gene expression; Insulin; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996481,0.0002079555,0.000193176,0.0004505822,0.00009228181,0.0003115524,0.0001528281,0.0003167765,0.001621263],"category_scores_gemma":[0.0004074879,0.00008377422,0.0001561112,0.0002827049,0.0003377459,0.0002162443,0.0002480271,0.000435955,0.0002117569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726608,"about_ca_system_score_gemma":0.000142747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001018307,"about_ca_topic_score_gemma":0.0001380381,"domain_scores_codex":[0.9998052,0.0000354287,0.00001680753,0.00004928988,0.00007212837,0.00002117906],"domain_scores_gemma":[0.9996656,0.00008148106,0.0001418224,0.00002992828,0.00004561864,0.00003551828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003346368,0.00005224934,0.02350118,0.0001232612,0.00003615625,0.0002343007,0.0000838921,0.0001626872,0.9639426,0.0003404373,0.00009888987,0.01108964],"study_design_scores_gemma":[0.00001951066,0.0008242384,0.1651664,0.00005661723,0.0001293919,0.00295201,0.0002192702,0.001456221,0.8217219,0.001226518,0.006209929,0.00001801681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970133,0.006972188,0.01808806,0.0001867955,0.00009616986,0.00006260984,0.0003828137,0.0001155232,0.003962867],"genre_scores_gemma":[0.9906571,0.001412284,0.006072576,0.0002136336,0.0000294076,0.00004208834,0.000329328,0.00001221036,0.001231303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001621263,"threshold_uncertainty_score":0.005423725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442158452453028,"score_gpt":0.2481899017066572,"score_spread":0.2237683171821269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}