{"id":"W3003551095","doi":"10.1111/xen.12570","title":"Epigenetic biomarkers indicate islet cell death in xenotransplantation","year":2020,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Juvenile Diabetes Research Foundation United Kingdom; Foundation for the National Institutes of Health","keywords":"Xenotransplantation; Epigenetics; Biology; Islet; DNA methylation; Biomarker; Transplantation; CpG site; Molecular biology; Cancer research; Genetics; Gene; Medicine; Gene expression; Insulin; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215013,0.0001810213,0.0002673503,0.0001679874,0.00005019792,0.00001857316,0.00006505541,0.0001185107,0.0002724412],"category_scores_gemma":[0.00002324378,0.0001766122,0.00007285315,0.0004058816,0.00003356455,0.0001198729,0.000003373306,0.0001617537,0.0002435554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000043679,"about_ca_system_score_gemma":0.00008209854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009036855,"about_ca_topic_score_gemma":0.000007428991,"domain_scores_codex":[0.9986905,0.00006888246,0.0003739769,0.0003308291,0.0002705324,0.0002652572],"domain_scores_gemma":[0.9994717,0.00009230291,0.00008113193,0.0001169247,0.00003462474,0.0002033043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002133969,0.0002554628,0.2920346,0.001423195,0.0001083552,0.0002301205,0.005016649,0.0004259098,0.6958371,0.000202999,0.0002459643,0.002085751],"study_design_scores_gemma":[0.008298644,0.0006565844,0.5272399,0.0002733314,0.0005039411,0.0000396102,0.0002673535,0.005599538,0.456026,0.0001401636,0.0005471405,0.0004077917],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811437,0.0002228154,0.007772208,0.001521444,0.00009790604,0.0004799975,0.00005385283,0.000123783,0.008584329],"genre_scores_gemma":[0.9945208,0.0005392597,0.002032357,0.002039147,0.00008409891,0.00003198717,0.000654116,0.00002670254,0.00007147057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2398111,"threshold_uncertainty_score":0.7202035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442158452453028,"score_gpt":0.2481899017066572,"score_spread":0.2237683171821269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}