{"id":"W3003584875","doi":"10.1111/febs.15228","title":"Evolutionary repression of chondrogenic genes in the vertebrate osteoblast","year":2020,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Light Source","keywords":"Chondrogenesis; Biology; Zebrafish; Vertebrate; Extant taxon; Gene; Cartilage; Evolutionary biology; Osteoblast; Cell type; Gene duplication; Cell biology; Anatomy; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002440349,0.0002532717,0.0011294,0.0001801561,0.00007810989,0.00001962501,0.0002109238,0.0001927675,0.0002225396],"category_scores_gemma":[0.00006010729,0.0001403977,0.0006019418,0.0002992598,0.00003410979,0.00006775444,0.00005179874,0.0006823197,0.00009702086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103748,"about_ca_system_score_gemma":0.0005065228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001387562,"about_ca_topic_score_gemma":0.000002382224,"domain_scores_codex":[0.9982547,0.0002690496,0.0006626905,0.0002104688,0.0003944264,0.0002086315],"domain_scores_gemma":[0.9990626,0.00006801259,0.0004253706,0.0002696424,0.00005545506,0.0001189449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004822559,0.00009256187,0.00003473038,0.001439558,0.00008559407,0.001147939,0.0001098695,1.792776e-7,0.00003451308,0.00003593724,0.001235302,0.9957356],"study_design_scores_gemma":[0.001302453,0.00105716,0.00001840463,0.02054403,0.001008722,0.01207152,0.00007978384,0.000003334902,0.00003167474,0.00009958663,0.9636548,0.0001285519],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002265434,0.9979227,0.000003903559,0.0001510078,0.0004000838,0.0005954122,0.00002226996,0.00001002779,0.0006680473],"genre_scores_gemma":[0.0001714191,0.9984971,0.0002605025,0.00005649936,0.0005801338,0.00003001598,0.00006417349,0.00003240973,0.0003077268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995607,"threshold_uncertainty_score":0.5725252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04371768327739813,"score_gpt":0.3222567971582612,"score_spread":0.2785391138808631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}