{"id":"W3003688072","doi":"10.1038/s41576-020-0215-2","title":"Selling direct-to-consumer epigenetic tests: are we ready?","year":2020,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Canadian Institutes of Health Research","keywords":"Scrutiny; Epigenetics; Genetic testing; Biology; Genetics; Political science; Law","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006409892,0.0007803421,0.002292251,0.001346789,0.0004320417,0.002739636,0.001958051,0.006302106,0.01015753],"category_scores_gemma":[0.01251018,0.0003751547,0.0008784625,0.00138799,0.002141342,0.003976445,0.001407549,0.006845292,0.003302086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001981765,"about_ca_system_score_gemma":0.002724825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001954943,"about_ca_topic_score_gemma":0.005242384,"domain_scores_codex":[0.9978327,0.0009413459,0.0001740893,0.0001853578,0.0007305247,0.0001360148],"domain_scores_gemma":[0.9877155,0.009989523,0.0006536084,0.0001705464,0.001088947,0.0003818561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009386322,0.00003592181,0.0001864014,0.008033086,0.0001059594,0.0001434063,0.00006861243,0.0001489979,0.0002670434,0.0194602,0.1121766,0.8592799],"study_design_scores_gemma":[0.00006230411,0.00004263693,0.0005697671,0.01357786,0.0001067878,0.000652993,0.0001139234,0.00008054759,0.0001294921,0.01680396,0.9678313,0.0000285218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004226589,0.9900866,0.0001791383,0.00766927,0.0007632131,0.000003146041,0.00001627506,0.00000681837,0.001233308],"genre_scores_gemma":[0.0009068875,0.9897774,0.0003453209,0.006859993,0.001173787,0.00001138719,0.00003282822,0.000006241907,0.0008860565],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01015753,"threshold_uncertainty_score":0.03398031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5825285439637741,"score_gpt":0.6145248246701527,"score_spread":0.03199628070637861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}