{"id":"W3003729382","doi":"10.1002/stem.3095","title":"Induced pluripotent stem cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary","funders":"Medical Research Council; Medical Research Council Canada; Rosetrees Trust","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; KLF4; SOX2; Cell biology; Embryonic stem cell; Dendritic cell; Epigenetics; Immunology; Phenotype; Cellular differentiation; Immune system; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187815,0.0003157429,0.000302121,0.0002812575,0.000132057,0.000407198,0.0001893621,0.0003125276,0.001894777],"category_scores_gemma":[0.000184712,0.0001619595,0.0002369091,0.0002208124,0.0001677223,0.0002327809,0.0002484669,0.0006972794,0.001098948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069898,"about_ca_system_score_gemma":0.0001737584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065892,"about_ca_topic_score_gemma":0.0001547452,"domain_scores_codex":[0.9997799,0.00002657842,0.00003661053,0.00004164059,0.00009013146,0.00002519348],"domain_scores_gemma":[0.999878,0.00002475688,0.00002330434,0.00003541933,0.00002503373,0.00001339904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003254082,0.00001978851,0.0003063419,0.00006788631,0.000004535348,0.00006731012,0.00001860764,0.0001760686,0.9926432,0.000281057,0.0001395096,0.006243287],"study_design_scores_gemma":[0.00001400788,0.0001449463,0.001311161,0.00001381137,0.00002751142,0.0003141874,0.00002090965,0.0008740076,0.9836382,0.0001904896,0.01344526,0.000005551179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7966136,0.008250907,0.1696477,0.0008604701,0.0003890737,0.0006002754,0.009434738,0.001541797,0.01266142],"genre_scores_gemma":[0.9361406,0.006640186,0.04276958,0.000310062,0.00007643747,0.0002699711,0.005978619,0.0001694911,0.007644987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001894777,"threshold_uncertainty_score":0.006338656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205980185804562,"score_gpt":0.2547674924443559,"score_spread":0.2341694738638997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}