{"id":"W3003729382","doi":"10.1002/stem.3095","title":"Induced pluripotent stem cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary","funders":"Medical Research Council; Medical Research Council Canada; Rosetrees Trust","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; KLF4; SOX2; Cell biology; Embryonic stem cell; Dendritic cell; Epigenetics; Immunology; Phenotype; Cellular differentiation; Immune system; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009755344,0.0007878119,0.001117082,0.0003350911,0.0001357605,0.0001982443,0.001266002,0.0007256793,0.00006173253],"category_scores_gemma":[0.00001124719,0.0008177841,0.0005379203,0.0003329733,0.0002190234,0.00007571716,0.0004379152,0.0005378554,0.00014342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002785123,"about_ca_system_score_gemma":0.0005370075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009476099,"about_ca_topic_score_gemma":0.0001541282,"domain_scores_codex":[0.9936303,0.0006715505,0.001519945,0.001862701,0.0008542903,0.001461143],"domain_scores_gemma":[0.9958003,0.0004211336,0.0005602755,0.00244343,0.0003951079,0.0003798261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00114783,0.0008310222,0.001382946,0.0005798899,0.0002439868,0.00003386194,0.0003424615,0.00127951,0.9861838,0.000003558685,0.0002110523,0.007760047],"study_design_scores_gemma":[0.004831824,0.00151068,0.000542729,0.0002716189,0.00006359857,0.000007509849,0.0007026626,0.001193099,0.9800524,0.00001402354,0.009927778,0.0008820634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908025,0.002184504,0.000930123,0.00002240514,0.001105937,0.004477696,0.0003312956,0.00006248132,0.00008312018],"genre_scores_gemma":[0.9920164,0.0004964936,0.002087693,0.0002321389,0.0001735845,0.0002404259,0.0002523421,0.000269153,0.004231715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009716725,"threshold_uncertainty_score":0.9994273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205980185804562,"score_gpt":0.2547674924443559,"score_spread":0.2341694738638997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}