{"id":"W3003752356","doi":"10.1016/j.chom.2020.01.006","title":"Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production","year":2020,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":523,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; National Starch and Chemical Company; Canada Foundation for Innovation; University of Michigan","keywords":"Butyrate; Biology; Gut microbiome; Resistant starch; Propionate; Microbiome; Biochemistry; Dietary fiber; Short-chain fatty acid; Gut flora; Metabolism; Prebiotic; Computational biology; Starch; Food science; Genetics; Fermentation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009380638,0.0003089712,0.0002347978,0.00003961747,0.0001759348,0.00004531277,0.0001944312,0.0002105194,0.00004227695],"category_scores_gemma":[0.00001852541,0.0002595046,0.00009470942,0.0001777503,0.00009412244,0.00001402269,0.0001429838,0.0001843151,0.00003343042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003108349,"about_ca_system_score_gemma":0.00007697272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001950832,"about_ca_topic_score_gemma":0.00003048774,"domain_scores_codex":[0.9983789,0.00007785384,0.000274448,0.0007884492,0.0001051963,0.0003751797],"domain_scores_gemma":[0.9992216,0.000004764659,0.0001076591,0.0004004838,0.00009862119,0.0001668668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003092494,0.00004088493,0.0007353728,0.000120918,0.00002902451,0.000003617781,0.0002082911,0.0001663359,0.9904911,8.188729e-7,0.005762634,0.002131736],"study_design_scores_gemma":[0.0003805617,0.0003920891,0.01412633,0.00003116291,0.00003346955,0.00002501031,0.00004445458,0.00002748909,0.9621623,0.000005573813,0.02242871,0.0003428306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995856,0.001314458,0.0007231289,0.0008877497,0.0001922147,0.0006017431,0.0001019847,0.00004559401,0.0002771112],"genre_scores_gemma":[0.9929265,0.0002142304,0.004102234,0.0005557674,0.0004428937,0.00001112329,0.001072821,0.00005924814,0.0006151212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0283288,"threshold_uncertainty_score":0.9999857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114484930959097,"score_gpt":0.2369168163132436,"score_spread":0.2257719670036526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}