{"id":"W3003814697","doi":"10.1128/aac.01910-19","title":"Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université Laval","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Foscarnet; Virology; Mutation; Biology; Molecular biology; Polymerase; Recombinant DNA; Cytomegalovirus; DNA; Enzyme; DNA polymerase; Human cytomegalovirus; Virus; Genetics; Herpesviridae; Ganciclovir; Gene; Biochemistry; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085932,0.0002434217,0.000160221,0.0001127457,0.00006823189,0.0001509292,0.0001052858,0.000201032,0.0006661278],"category_scores_gemma":[0.000309443,0.00007447224,0.0001444383,0.00006550123,0.0002969353,0.0001388318,0.0001260123,0.000210159,0.0000936695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772672,"about_ca_system_score_gemma":0.0001152604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526658,"about_ca_topic_score_gemma":0.0004079729,"domain_scores_codex":[0.9998776,0.00002705322,0.00001095437,0.00002571255,0.00003843986,0.0000203314],"domain_scores_gemma":[0.9998775,0.00004518769,0.00004047246,0.00001191426,0.00000974253,0.00001510058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007662876,0.0000146098,0.0006377416,0.00001335388,0.000005048308,0.0001370176,0.00001707339,0.00006827675,0.9982265,0.00003865244,0.000005779111,0.0007594767],"study_design_scores_gemma":[0.00001269187,0.0006735278,0.007726624,0.000003514426,0.00001321692,0.001391553,0.00004154536,0.00105475,0.9886547,0.0000433655,0.000380228,0.000004176841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992967,0.0001163362,0.0003786705,0.000009423108,0.000002414766,0.000006698624,0.00002632483,0.000006851385,0.0001566452],"genre_scores_gemma":[0.9994982,0.00006638855,0.0002456694,0.000005275422,9.810346e-7,0.000003415993,0.00005974574,0.000003362591,0.0001170614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006661278,"threshold_uncertainty_score":0.002228439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03298610116185939,"score_gpt":0.3146781775209321,"score_spread":0.2816920763590727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}