{"id":"W3003947341","doi":"10.1093/cvr/cvaa017","title":"MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling","year":2020,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canada Foundation for Innovation; Stollery Children’s Hospital Foundation; National Institutes of Health; Canadian Institutes of Health Research; Royal Alexandra Hospital Foundation; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Cardiotoxicity; Extracellular matrix; Doxorubicin; Intracellular; Matrix metalloproteinase; Extracellular; Medicine; Pharmacology; Chemistry; Cardiology; Cell biology; Internal medicine; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004699374,0.000362922,0.001040983,0.0002087825,0.000421248,0.0001536365,0.0002249946,0.0003909774,0.00003412663],"category_scores_gemma":[0.0005061383,0.000369886,0.001092691,0.0009039533,0.0003200662,0.0002332999,0.0002166719,0.001518778,0.00006687024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196826,"about_ca_system_score_gemma":0.0001635211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001071812,"about_ca_topic_score_gemma":7.206681e-7,"domain_scores_codex":[0.9946273,0.0007896208,0.0005549549,0.001110005,0.002008894,0.0009092527],"domain_scores_gemma":[0.9977633,0.0001438691,0.00007499364,0.0008614521,0.0004304798,0.0007259201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001462963,0.00005375089,0.0005192378,0.0006239281,0.001415369,0.0003146553,0.0008946277,0.0005381615,0.9712163,0.00007124781,0.001792186,0.02241429],"study_design_scores_gemma":[0.002414541,0.0002208747,0.00009843154,0.0002697346,0.0003914295,0.0002223896,0.0006975036,0.00618678,0.9210656,0.0001023451,0.06790946,0.0004209486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9080989,0.07304945,0.01419395,0.001874931,0.00009314817,0.001706076,0.00001542284,0.0001734478,0.0007946267],"genre_scores_gemma":[0.9942116,0.002633046,0.001052105,0.0001285275,0.001067569,0.00005760643,0.00006990919,0.0001147809,0.0006648327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08611268,"threshold_uncertainty_score":0.9998753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06733712674012228,"score_gpt":0.3256136343004394,"score_spread":0.2582765075603172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}