{"id":"W3003960114","doi":"","title":"Hypoxia-Inducible Factor 1 is required for hypoxia-induced resistance to doxorubicin in breast carcinoma cells","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Smoothened; Cyclopamine; Patched; Cancer research; Hedgehog signaling pathway; GLI1; Biology; Hedgehog; GLI2; Molecular biology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007008818,0.0002503143,0.0003105421,0.0002573054,0.0002283633,0.00005998146,0.0004832406,0.0002214798,0.00002705757],"category_scores_gemma":[0.000119653,0.0002521256,0.0001078675,0.0005962044,0.0001139016,0.000008167691,0.0002360264,0.0002405814,0.00003671863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561545,"about_ca_system_score_gemma":0.0004483557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001311014,"about_ca_topic_score_gemma":0.00222395,"domain_scores_codex":[0.9970497,0.0001526551,0.0003675251,0.000945647,0.0004545323,0.001029936],"domain_scores_gemma":[0.9984807,0.00008738281,0.00005717401,0.0006881442,0.0005132745,0.0001733332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003680121,0.0001398927,0.001427879,0.00007862019,0.00002700433,0.000009640129,0.0002033686,0.00001543181,0.9585148,0.00003479275,0.03865861,0.0005219645],"study_design_scores_gemma":[0.001573382,0.0001864096,0.008023416,0.00007066495,0.000004903985,0.000001527389,0.0001600649,0.000006168625,0.958855,0.0001355615,0.03069014,0.000292723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935337,0.001552218,0.0001047452,0.002068313,0.0002081368,0.001010475,0.000502386,0.00001767516,0.001002409],"genre_scores_gemma":[0.991903,0.00005335906,0.0003463463,0.0002603949,0.0007144564,0.0007268268,0.00003340829,0.00006800623,0.005894167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00796847,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08499094368648552,"score_gpt":0.3647150108860175,"score_spread":0.279724067199532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}