{"id":"W3003979838","doi":"10.1017/s1047951119003147","title":"Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised, multicentre, placebo-controlled, double-blind phase II trial","year":2020,"lang":"en","type":"article","venue":"Cardiology in the Young","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Tuberous sclerosis; Medicine; Everolimus; Subependymal giant cell astrocytoma; Rhabdomyoma; Placebo; Internal medicine; Pericardial effusion; Pediatrics; Cardiology; Surgery; Pathology; Glioma; Astrocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.008533515,0.001237973,0.004771776,0.0006188119,0.0007908191,0.0002207634,0.001602008,0.0006423247,0.00001685814],"category_scores_gemma":[0.001849411,0.0007998197,0.001463368,0.001719456,0.0007201158,0.0003377316,0.0005119421,0.001963263,0.00002062077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007034203,"about_ca_system_score_gemma":0.0007807488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009837118,"about_ca_topic_score_gemma":0.0005941533,"domain_scores_codex":[0.9878768,0.003877891,0.002364343,0.002067236,0.001355036,0.002458714],"domain_scores_gemma":[0.9926128,0.003907955,0.0005660521,0.001938777,0.0004993515,0.0004750662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9022937,0.002784426,0.07915806,0.0001216775,0.0025792,0.0001453763,0.00693727,0.001780972,0.001263367,0.00003764529,0.001218634,0.001679714],"study_design_scores_gemma":[0.9213927,0.01460168,0.05594228,0.0002182692,0.001507653,0.0002566857,0.003472109,0.001310491,0.0002240109,0.00003076105,0.0002259405,0.0008174257],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6426978,0.0005168504,0.000113639,0.001584505,0.0003310132,0.3543491,0.0001434547,0.000106049,0.0001576723],"genre_scores_gemma":[0.628502,0.00003583375,0.0001821711,0.0004173683,0.00117352,0.3694207,0.00007935227,0.0001599206,0.000029205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02321578,"threshold_uncertainty_score":0.9994453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09736855961194424,"score_gpt":0.3581867958306669,"score_spread":0.2608182362187227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}