{"id":"W3003979838","doi":"10.1017/s1047951119003147","title":"Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised, multicentre, placebo-controlled, double-blind phase II trial","year":2020,"lang":"en","type":"article","venue":"Cardiology in the Young","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Tuberous sclerosis; Medicine; Everolimus; Subependymal giant cell astrocytoma; Rhabdomyoma; Placebo; Internal medicine; Pericardial effusion; Pediatrics; Cardiology; Surgery; Pathology; Glioma; Astrocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003055501,0.002183393,0.003109433,0.000402717,0.0004358075,0.001094455,0.001005319,0.00222068,0.007674105],"category_scores_gemma":[0.002745133,0.0006816097,0.001693208,0.0003698082,0.001005405,0.0009221748,0.0005789417,0.00235645,0.001248706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005540615,"about_ca_system_score_gemma":0.001464381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000658629,"about_ca_topic_score_gemma":0.001596841,"domain_scores_codex":[0.9988737,0.0006597024,0.0001079445,0.0001353256,0.0000991814,0.0001241639],"domain_scores_gemma":[0.999052,0.0002329629,0.0002884188,0.00008183392,0.00008775213,0.000256926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9707025,0.004381848,0.001022253,0.003861813,0.0008996045,0.00007602508,0.00007034497,0.0004011501,0.00274011,0.0003161088,0.002422166,0.01310611],"study_design_scores_gemma":[0.9723414,0.02387276,0.001349605,0.0001496889,0.0002985742,0.00005226766,0.00001427823,0.0001377713,0.0002446231,0.0001173889,0.001410297,0.00001143028],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8169427,0.02690893,0.002976824,0.003259816,0.001768529,0.1227182,0.01441903,0.0004582423,0.01054757],"genre_scores_gemma":[0.7805256,0.01197339,0.008903104,0.005238519,0.0008649717,0.1769646,0.008032166,0.0000842386,0.007413429],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007674105,"threshold_uncertainty_score":0.02567244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09736855961194424,"score_gpt":0.3581867958306669,"score_spread":0.2608182362187227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}