{"id":"W3003987102","doi":"10.1007/978-3-319-69287-6_24","title":"Safety Considerations for Osteoporosis Therapies","year":2020,"lang":"en","type":"book-chapter","venue":"Contemporary Endocrinology","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Medicine; Denosumab; Teriparatide; Osteoporosis; Adverse effect; Osteonecrosis of the jaw; Raloxifene; Intensive care medicine; Bisphosphonate; Internal medicine; Tamoxifen; Bone mineral; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003028879,0.0006516519,0.0005667334,0.001182977,0.001329891,0.003679344,0.0009936544,0.005858611,0.03062172],"category_scores_gemma":[0.006570587,0.0003631432,0.0005453772,0.0005116682,0.002420464,0.003166365,0.00159399,0.007042013,0.01102208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001532244,"about_ca_system_score_gemma":0.002637436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038261,"about_ca_topic_score_gemma":0.002970879,"domain_scores_codex":[0.998181,0.0005915218,0.00006910998,0.00009858848,0.0009754839,0.00008426216],"domain_scores_gemma":[0.9960867,0.002836791,0.0001508184,0.0001615082,0.0006316353,0.0001326436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004269652,0.00007855533,0.00008770772,0.0004628071,0.000009300007,0.0004108464,0.0003798364,0.0004042682,0.0006728537,0.3815401,0.4215445,0.1943666],"study_design_scores_gemma":[0.00000558891,0.00002457969,0.00007468308,0.0004349357,0.000004686449,0.0004486753,0.00006701683,0.00009223501,0.0001110416,0.07471056,0.9240205,0.000005596921],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"review","genre_scores_codex":[0.0008030898,0.1047738,0.00865999,0.09285556,0.01078218,0.00007503628,0.0001161581,0.0001061912,0.7818279],"genre_scores_gemma":[0.01677742,0.06421116,0.00963979,0.08922932,0.01769422,0.0002090946,0.0001725028,0.0001496879,0.8019168],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.03062172,"threshold_uncertainty_score":0.1024398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09234821866819627,"score_gpt":0.3088067463070316,"score_spread":0.2164585276388353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}