{"id":"W3003998672","doi":"10.1039/c9mt00285e","title":"pH dependence of the non-cooperative binding of Bi3+ to human apo-metallothionein 1A: kinetics, speciation, and stoichiometry","year":2020,"lang":"en","type":"article","venue":"Metallomics","topic":"Trace Elements in Health","field":"Nursing","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario","keywords":"Metallothionein; Chemistry; Cysteine; Metalloprotein; Stoichiometry; Adduct; Divalent; Kinetics; Stereochemistry; Inorganic chemistry; Medicinal chemistry; Metal; Zinc; Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004152511,0.0003171143,0.0002820058,0.0002038071,0.0001694295,0.0002478333,0.0004311748,0.0003247989,0.00161969],"category_scores_gemma":[0.0009241878,0.0002958984,0.0002253738,0.0002304241,0.0002065676,0.0002434428,0.000192443,0.0005564327,0.000732598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752881,"about_ca_system_score_gemma":0.000186123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002746329,"about_ca_topic_score_gemma":0.001878685,"domain_scores_codex":[0.999563,0.0001018114,0.00002634453,0.00009331747,0.0001402933,0.00007527314],"domain_scores_gemma":[0.999369,0.0002834669,0.00009489178,0.00004264856,0.0001627298,0.00004728262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005177219,0.00006699534,0.00147645,0.0001020518,0.00003512266,0.00005686298,0.000170791,0.0005381808,0.9942679,0.00008346091,0.0001307116,0.00255369],"study_design_scores_gemma":[0.00001387744,0.0003740195,0.01003661,0.000008752311,0.00001481049,0.0001112594,0.00008652295,0.007561576,0.980935,0.00005860738,0.0007805215,0.00001838978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931092,0.001099736,0.003596609,0.00007674327,0.00001764235,0.00004928367,0.0003179662,0.0001217632,0.001611023],"genre_scores_gemma":[0.9964405,0.0003035123,0.001182459,0.00003515841,0.000004219336,0.00003017813,0.0002432069,0.00001970557,0.001741045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002746329,"threshold_uncertainty_score":0.005460739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099308511245042,"score_gpt":0.2998222859191584,"score_spread":0.268829200806708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}