{"id":"W3004091996","doi":"10.18632/aging.102738","title":"Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Fudan University; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Entorhinal cortex; Internal medicine; Hippocampus; Body mass index; Cognitive decline; Alzheimer's disease; Temporal lobe; Risk factor; Psychology; Longitudinal study; Oncology; Medicine; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Endocrinology; Disease; Dementia; Neuroscience; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00129584,0.0004413287,0.0004099551,0.0004963365,0.0008228555,0.0008147912,0.0003786218,0.0007187924,0.001159621],"category_scores_gemma":[0.001709883,0.0005872683,0.000695314,0.0006419986,0.000242328,0.0006073725,0.0004641998,0.001322035,0.000366209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454921,"about_ca_system_score_gemma":0.0003887884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004788632,"about_ca_topic_score_gemma":0.005291407,"domain_scores_codex":[0.9997318,0.00007109592,0.0000202084,0.00008979057,0.00003415207,0.00005276794],"domain_scores_gemma":[0.998686,0.0001052905,0.0003408472,0.0002243608,0.000231797,0.0004116647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001107875,0.0003578655,0.9955657,0.00001199555,0.0002727151,0.0001552178,0.0002084564,0.00002267537,0.0006543224,0.00002809841,0.0001595522,0.001455561],"study_design_scores_gemma":[0.00003195148,0.000406388,0.9986988,0.000007140083,0.00009970656,0.0002009933,0.0001195498,0.0001303993,0.00005152792,0.00003407227,0.0002138176,0.000005612884],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990158,0.0003623037,0.0001179667,0.00005144331,0.00001243586,0.000009655694,0.0002231927,0.000003897163,0.0002032489],"genre_scores_gemma":[0.9987503,0.0001889642,0.000178656,0.00007260444,0.00002328789,0.00001501453,0.0004134419,0.000003951474,0.0003537522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004788632,"threshold_uncertainty_score":0.009521544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242263691110593,"score_gpt":0.3703939791040524,"score_spread":0.2461676099929931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}