{"id":"W3004091996","doi":"10.18632/aging.102738","title":"Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Fudan University; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Entorhinal cortex; Internal medicine; Hippocampus; Body mass index; Cognitive decline; Alzheimer's disease; Temporal lobe; Risk factor; Psychology; Longitudinal study; Oncology; Medicine; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Endocrinology; Disease; Dementia; Neuroscience; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007287127,0.0002159139,0.0003152487,0.00005405928,0.0002080679,0.00004319228,0.00009893908,0.00003000206,0.0001500282],"category_scores_gemma":[0.0002058712,0.0001751832,0.0001471412,0.0002415266,0.00004637025,0.0001438622,0.00009352362,0.0001684583,0.00008350209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005255673,"about_ca_system_score_gemma":0.0004300555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008333197,"about_ca_topic_score_gemma":0.000005211582,"domain_scores_codex":[0.9983308,0.00005365629,0.0001803306,0.0005504144,0.0004512991,0.0004334526],"domain_scores_gemma":[0.9983802,0.00005066449,0.00005750344,0.0002466493,0.000187708,0.00107726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001727577,0.001471294,0.9833439,0.0001341987,0.009269516,0.0005427725,0.001764439,0.000001100767,0.00002050686,0.000008984599,0.0004667497,0.001248973],"study_design_scores_gemma":[0.00392558,0.001269548,0.9910977,0.00006202663,0.001801869,0.000002718592,0.0002925295,0.0008279684,0.0003687688,0.00006568497,0.00009897706,0.0001865519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863549,0.003180772,0.0002407273,0.004037797,0.00002859458,0.00567437,0.0002715028,0.0001510266,0.00006029902],"genre_scores_gemma":[0.9983988,0.000005766377,0.0001679095,0.0004816258,0.0002189252,0.0006335513,0.00003772378,0.00003742117,0.00001830943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01204386,"threshold_uncertainty_score":0.7143763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242263691110593,"score_gpt":0.3703939791040524,"score_spread":0.2461676099929931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}