{"id":"W3004093423","doi":"10.1016/j.exphem.2020.01.005","title":"Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; New York State Stem Cell Science; Doris Duke Charitable Foundation","keywords":"Biology; Haematopoiesis; Stem cell; Somatic cell; Population; Myeloid; Genetics; Lineage (genetic); Progenitor cell; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003986761,0.0001312326,0.0002366428,0.00002386106,0.00001888281,0.000006529579,0.00009675997,0.0001111345,0.00002194528],"category_scores_gemma":[0.00001217487,0.0001427688,0.00004659966,0.00004568707,0.00008141133,0.00000284691,0.000156551,0.00006644001,0.000003192007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006618459,"about_ca_system_score_gemma":0.00003445156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003357198,"about_ca_topic_score_gemma":0.00001409028,"domain_scores_codex":[0.9991345,0.0000263675,0.0002897974,0.0002957635,0.00006308474,0.0001904252],"domain_scores_gemma":[0.9996538,0.0000311489,0.00008756827,0.0001185119,0.00001672688,0.00009223948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000212049,0.0002166138,0.01446299,0.0001388845,0.00004760531,0.00005999646,0.001630626,0.00006102517,0.9800591,0.002723129,0.0002524242,0.0001354969],"study_design_scores_gemma":[0.00111976,0.0003966265,0.0001310745,0.00002690391,0.000007620456,0.0001198759,0.0008929634,0.0003073799,0.9963452,0.000007269215,0.0005021878,0.0001431565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898788,0.009540031,0.00004725939,0.0001061903,0.0000729235,0.0001402413,0.0000197916,0.000005672553,0.000189088],"genre_scores_gemma":[0.9988748,0.0001224524,0.0004863408,0.0003805194,0.00007383914,0.00001597541,0.0000210372,0.00001648376,0.00000850046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01628602,"threshold_uncertainty_score":0.5821943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412750497275087,"score_gpt":0.257857583510291,"score_spread":0.2437300785375401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}