{"id":"W3004093423","doi":"10.1016/j.exphem.2020.01.005","title":"Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; New York State Stem Cell Science; Doris Duke Charitable Foundation","keywords":"Biology; Haematopoiesis; Stem cell; Somatic cell; Population; Myeloid; Genetics; Lineage (genetic); Progenitor cell; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703962,0.00007533904,0.000129962,0.000343446,0.0001684525,0.0002257308,0.000159094,0.0001863224,0.001443442],"category_scores_gemma":[0.0004256956,0.00009326317,0.00007389971,0.0001416635,0.0001128952,0.0001279661,0.0002415099,0.0002412563,0.0002423932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249722,"about_ca_system_score_gemma":0.0001336433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195556,"about_ca_topic_score_gemma":0.0007284505,"domain_scores_codex":[0.9998853,0.00002068267,0.000011953,0.00002858744,0.00003552283,0.00001790088],"domain_scores_gemma":[0.9997645,0.0000719189,0.00003450743,0.000032698,0.00004104793,0.00005536408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007461595,0.00004975084,0.0359152,0.000045783,0.00001226024,0.000732785,0.0002972611,0.0001140739,0.9421625,0.002564741,0.00036189,0.01699773],"study_design_scores_gemma":[0.00007994025,0.001215248,0.3216895,0.00003578041,0.00009863576,0.01224372,0.0003980328,0.002322247,0.6378063,0.001541126,0.02255296,0.00001650008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943599,0.001317282,0.001627746,0.00003027147,0.00001375841,0.00001583318,0.0003130815,0.00003306294,0.002289021],"genre_scores_gemma":[0.9966068,0.0003021887,0.0009597027,0.00002556019,0.0000132721,0.00001702445,0.0005364369,0.00001410322,0.001524844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443442,"threshold_uncertainty_score":0.004828811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412750497275087,"score_gpt":0.257857583510291,"score_spread":0.2437300785375401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}