{"id":"W3004229270","doi":"10.1128/msystems.00404-19","title":"Effects of Antibiotic Pretreatment of an Ulcerative Colitis-Derived Fecal Microbial Community on the Integration of Therapeutic Bacteria <i>In Vitro</i>","year":2020,"lang":"en","type":"article","venue":"mSystems","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Guelph","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Rifaximin; Antibiotics; Ulcerative colitis; Fecal bacteriotherapy; Antimicrobial; Gut flora; Feces; Antibiotic resistance; Colonisation resistance; Bacteria; Biology; Medicine; Microbiology; Clostridium difficile; Immunology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002222347,0.0001067983,0.00025746,0.000018264,0.00003656753,0.000005440072,0.0001336262,0.00008988849,0.00000223059],"category_scores_gemma":[0.00003349705,0.00007507437,0.00005850879,0.00006644463,0.00007979246,0.000002294914,0.00002893146,0.0001003632,7.829006e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000231257,"about_ca_system_score_gemma":0.00006453169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004655612,"about_ca_topic_score_gemma":0.000241857,"domain_scores_codex":[0.9986498,0.0007979861,0.0002625842,0.0001200147,0.000065158,0.0001044603],"domain_scores_gemma":[0.9994636,0.00005517329,0.0001720916,0.0002089615,0.00006727153,0.00003286797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000724192,0.0002621388,0.0001426693,0.0003605428,0.00004388376,5.075763e-7,0.00153977,0.000004062455,0.9965579,0.00005369676,0.00002575213,0.0002848921],"study_design_scores_gemma":[0.0007405094,0.001640116,0.02399421,0.0001276004,0.00001663622,0.0000017516,0.0004244222,0.00004899475,0.972904,0.000002637029,0.00004295869,0.00005618731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989099,0.00008689358,0.00007220053,0.00008994665,0.00006489819,0.0006318386,0.00006013692,0.000002767502,0.00008142853],"genre_scores_gemma":[0.9996101,0.00001875507,0.00005655113,0.0001719083,0.00003210125,0.000006035025,0.00008839985,0.000009593583,0.000006605672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02385155,"threshold_uncertainty_score":0.3061444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033703772273029,"score_gpt":0.2608080714935925,"score_spread":0.2404710337708622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}