{"id":"W3004229270","doi":"10.1128/msystems.00404-19","title":"Effects of Antibiotic Pretreatment of an Ulcerative Colitis-Derived Fecal Microbial Community on the Integration of Therapeutic Bacteria <i>In Vitro</i>","year":2020,"lang":"en","type":"article","venue":"mSystems","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Guelph","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Rifaximin; Antibiotics; Ulcerative colitis; Fecal bacteriotherapy; Antimicrobial; Gut flora; Feces; Antibiotic resistance; Colonisation resistance; Bacteria; Biology; Medicine; Microbiology; Clostridium difficile; Immunology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485643,0.00031517,0.0002567356,0.0001233084,0.000120906,0.0002913423,0.0001278847,0.0002257301,0.0008482565],"category_scores_gemma":[0.0002554444,0.0000861626,0.0001753684,0.00009423086,0.000192004,0.0001489112,0.0002069441,0.0003428539,0.0001594206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129793,"about_ca_system_score_gemma":0.0001963303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005107343,"about_ca_topic_score_gemma":0.0009873849,"domain_scores_codex":[0.9997591,0.00008865672,0.00002339745,0.00004267464,0.00003928457,0.00004689316],"domain_scores_gemma":[0.9997935,0.00007354486,0.00005039545,0.00002346455,0.00002053892,0.00003860263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005684207,0.0002904793,0.0002827123,0.00003400956,0.000005789246,0.00003474654,0.00001599931,0.00009158679,0.9965584,0.00002078659,0.0000254652,0.002071566],"study_design_scores_gemma":[0.00001617991,0.005786195,0.003147433,0.00000710467,0.00001723034,0.00006874085,0.00003740987,0.0005915939,0.9899071,0.00001292981,0.0004037528,0.000004311358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998292,0.0002981205,0.0006662512,0.00003537657,0.00002596857,0.00002660717,0.00008239517,0.00002045702,0.0005528054],"genre_scores_gemma":[0.9953744,0.0003495497,0.003061286,0.0000609119,0.00001315382,0.00002750638,0.0002426829,0.00001152516,0.0008589279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008482565,"threshold_uncertainty_score":0.002837718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033703772273029,"score_gpt":0.2608080714935925,"score_spread":0.2404710337708622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}