{"id":"W3004273640","doi":"10.1074/jbc.ra119.010476","title":"The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1)","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Toronto","funders":"Government of Canada; Institute of Cancer Research; Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Formins; RHOA; IQGAP1; Cell biology; Actin; Actin cytoskeleton; MDia1; Chemistry; Actin remodeling; Protein filament; Cytoskeleton; Scaffold protein; Biology; Biochemistry; Signal transduction; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003202593,0.0001235661,0.0001816137,0.000006628105,0.0001655354,0.00003296852,0.0002858149,0.0001676933,0.0000311478],"category_scores_gemma":[0.0009962849,0.00006425448,0.0001597724,0.00008658412,0.000128441,0.000007743621,0.0001464374,0.0002670778,6.703251e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008739543,"about_ca_system_score_gemma":0.00006703617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005121246,"about_ca_topic_score_gemma":0.000002397367,"domain_scores_codex":[0.9991266,0.00007139036,0.0003592655,0.0001562979,0.0001288208,0.0001576548],"domain_scores_gemma":[0.9989667,0.0001332853,0.0005452063,0.0001430037,0.0001166779,0.0000951143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001854213,0.00003597368,0.0001051505,0.0000148909,0.00006603487,0.000003701425,0.00002970184,0.000004955698,0.9944696,0.0000179289,0.0001361128,0.004930549],"study_design_scores_gemma":[0.0002343297,0.0004531372,0.0002942002,0.00002807316,0.0000177753,0.00004759009,0.0001655975,0.000123212,0.9937741,0.0001416756,0.004637888,0.0000824186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966967,0.001022961,0.0002525155,0.001378422,0.00006927559,0.00008393722,0.000006414354,0.000003449436,0.0004863808],"genre_scores_gemma":[0.9983894,0.001064306,0.0001215156,0.00007189817,0.0002622072,0.000002874798,0.000003980843,0.000007531285,0.00007629154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004848131,"threshold_uncertainty_score":0.2620221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671292648591682,"score_gpt":0.2372536128893813,"score_spread":0.2205406864034644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}