{"id":"W3004286285","doi":"10.1007/s00210-020-01829-x","title":"Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract","year":2020,"lang":"en","type":"article","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Uniwersytet Medyczny w Lodzi; Ministerstwo Edukacji i Nauki","keywords":"TRPV1; Irritable bowel syndrome; Capsaicin; Medicine; Stimulation; Pharmacology; Ussing chamber; Nociception; Desensitization (medicine); Nociceptor; Capsazepine; Transient receptor potential channel; Gastrointestinal tract; Internal medicine; Endocrinology; Chemistry; Secretion; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788138,0.0005724442,0.0006449005,0.0004097946,0.000139783,0.0003047373,0.0004666627,0.0006275073,0.001309037],"category_scores_gemma":[0.0001279769,0.000218364,0.0005880236,0.0002208798,0.0002894792,0.0005989558,0.0001660749,0.001328094,0.000300889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971335,"about_ca_system_score_gemma":0.0001705624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00023594,"about_ca_topic_score_gemma":0.0003424277,"domain_scores_codex":[0.9998348,0.00002875857,0.00001230683,0.00003618792,0.00003234011,0.00005569707],"domain_scores_gemma":[0.999927,0.00001142173,0.0000172874,0.00001067302,0.00001328325,0.00002037466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003444997,0.0001958687,0.00004475647,0.00007276959,0.000005353178,0.00003673654,0.00001181084,0.00006110603,0.9974361,0.00007001153,0.00002679728,0.001694315],"study_design_scores_gemma":[0.0002268933,0.01071503,0.002746163,0.00001688967,0.0000716318,0.0003771632,0.00005123025,0.001028083,0.9821976,0.0001222701,0.00243511,0.00001185767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882475,0.004542477,0.004833265,0.0003191653,0.00009446465,0.0001850117,0.0004705749,0.0001481105,0.001159485],"genre_scores_gemma":[0.9845194,0.005427279,0.004721023,0.0001782999,0.00003963435,0.0003047797,0.0007901089,0.00004040802,0.003979011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309037,"threshold_uncertainty_score":0.004379153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03251115643941127,"score_gpt":0.2774993591021175,"score_spread":0.2449882026627062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}