{"id":"W3004286746","doi":"10.1016/j.molcel.2020.01.006","title":"Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Hospital for Sick Children; Occupational Cancer Research Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; EIF4G; Neuroscience; Synaptic plasticity; Translation (biology); Alternative splicing; RNA-binding protein; EIF4E; Genetics; RNA; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253053,0.0005928936,0.0002974691,0.0005024279,0.000351086,0.0005314607,0.0002959915,0.0005946902,0.002288514],"category_scores_gemma":[0.0004378949,0.0002545442,0.0003520551,0.0001301783,0.000523604,0.0003781167,0.0005639642,0.0005410626,0.0004392197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004983696,"about_ca_system_score_gemma":0.0002448441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007361317,"about_ca_topic_score_gemma":0.001329288,"domain_scores_codex":[0.9998061,0.00002781762,0.00002104086,0.00005521216,0.00005127972,0.00003850077],"domain_scores_gemma":[0.9997717,0.00003962188,0.00007739668,0.00002733406,0.00003558613,0.00004842432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004472958,0.00001954703,0.003897059,0.00004178042,0.00003098725,0.0009965001,0.0000687338,0.0004599679,0.9867226,0.001559692,0.0002941795,0.005461629],"study_design_scores_gemma":[0.00004039365,0.0001697397,0.07162382,0.00002654758,0.00004882953,0.001782437,0.0003273434,0.004826779,0.9143648,0.002399644,0.004363733,0.00002593127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912744,0.001053709,0.004952729,0.0002923668,0.0001104108,0.000009288809,0.0002784016,0.0002107448,0.001817987],"genre_scores_gemma":[0.9946457,0.0002467083,0.002619643,0.00005434937,0.00001503035,0.00001422149,0.0001768007,0.00005925173,0.002168216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002288514,"threshold_uncertainty_score":0.007655859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087360777708563,"score_gpt":0.2255572849337736,"score_spread":0.214683677156688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}