{"id":"W3004303031","doi":"10.1038/s41375-020-0711-6","title":"Daratumumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: extended follow-up of POLLUX, a randomized, open-label, phase 3 study","year":2020,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Queen Elizabeth II Health Sciences Centre; Institute of Cancer Research; University of Calgary","funders":"Janssen Research and Development; Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University; Yale University","keywords":"Lenalidomide; Medicine; Internal medicine; Daratumumab; Dexamethasone; Multiple myeloma; Population; Gastroenterology; Refractory (planetary science); Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003090736,0.0009188696,0.001986775,0.0003444632,0.0004750084,0.001311514,0.0006240178,0.0008390857,0.001829681],"category_scores_gemma":[0.001398674,0.0005761127,0.002102813,0.0003190493,0.0006324928,0.000876808,0.000409588,0.002187068,0.0003896897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008192065,"about_ca_system_score_gemma":0.0008887411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009855574,"about_ca_topic_score_gemma":0.001880522,"domain_scores_codex":[0.9990257,0.0006082801,0.00004746939,0.0001183125,0.00008934444,0.0001108269],"domain_scores_gemma":[0.9991952,0.0001579272,0.0002233035,0.00007861702,0.00005117132,0.0002937904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9136631,0.01418584,0.007975146,0.0004518302,0.00295963,0.0001710911,0.0001363734,0.0005914063,0.007148655,0.00008161204,0.001207079,0.05142825],"study_design_scores_gemma":[0.6521602,0.2961427,0.04331313,0.00007463217,0.002272302,0.0003188373,0.0000956897,0.001392394,0.001716366,0.0001583511,0.002306907,0.00004848329],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949815,0.002885935,0.0002726788,0.0001813009,0.000123306,0.0006111133,0.0003158162,0.00004813205,0.0005801262],"genre_scores_gemma":[0.9956902,0.001041329,0.0005551747,0.0005354632,0.0001599082,0.0004951536,0.0006138689,0.000009969825,0.0008990116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003090736,"threshold_uncertainty_score":0.01634556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06341334890599047,"score_gpt":0.3557824096760606,"score_spread":0.2923690607700701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}