{"id":"W3004303031","doi":"10.1038/s41375-020-0711-6","title":"Daratumumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: extended follow-up of POLLUX, a randomized, open-label, phase 3 study","year":2020,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Queen Elizabeth II Health Sciences Centre; Institute of Cancer Research; University of Calgary","funders":"Janssen Research and Development; Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University; Yale University","keywords":"Lenalidomide; Medicine; Internal medicine; Daratumumab; Dexamethasone; Multiple myeloma; Population; Gastroenterology; Refractory (planetary science); Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000958133,0.0003953854,0.001859887,0.0002478707,0.0001124098,0.0000596781,0.0003426391,0.0001599966,0.0001297659],"category_scores_gemma":[0.003366132,0.0003130571,0.0001276394,0.0005620002,0.0002678699,0.0002203456,0.0004087629,0.0005933168,0.00003325572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005847837,"about_ca_system_score_gemma":0.0007967549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002124854,"about_ca_topic_score_gemma":0.0003979839,"domain_scores_codex":[0.9965183,0.0006363182,0.0008775212,0.00075897,0.0006443723,0.0005644972],"domain_scores_gemma":[0.9974411,0.00100166,0.0002576072,0.0005500219,0.0001342361,0.0006153783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9005759,0.005241921,0.01792486,0.0003485853,0.001500156,0.003102618,0.007194368,0.00001152867,0.02307375,0.00006675298,0.0008346994,0.04012483],"study_design_scores_gemma":[0.9719147,0.003768263,0.008041672,0.0001869162,0.0003279216,0.00003710146,0.001300059,0.01031934,0.003526323,0.00004916497,0.0002539573,0.0002745823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913469,0.001599543,0.000102688,0.0004448014,0.00009652349,0.005102959,0.00005833755,0.00005466019,0.001193616],"genre_scores_gemma":[0.9963413,0.0001593793,0.001893096,0.0002959394,0.00007855,0.0003780027,0.00006542215,0.00006021643,0.0007281235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07133877,"threshold_uncertainty_score":0.9999322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06341334890599047,"score_gpt":0.3557824096760606,"score_spread":0.2923690607700701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}