{"id":"W3004333708","doi":"10.1038/s41467-020-14377-y","title":"Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Argonne National Laboratory; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"APOBEC3G; Dimer; Cytidine deaminase; APOBEC; Linker; RNA; Deamination; Biology; Chemistry; Biophysics; Cell biology; DNA; Genetics; Biochemistry; Enzyme; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007707309,0.0001971961,0.000104432,0.00009832145,0.0002119108,0.0002579821,0.0003616963,0.0005187963,0.0004896335],"category_scores_gemma":[0.0001163906,0.0001127936,0.0001369615,0.00008312947,0.000260338,0.0004934488,0.0001361452,0.0005377531,0.0001598354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625665,"about_ca_system_score_gemma":0.0004277546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001978291,"about_ca_topic_score_gemma":0.001453284,"domain_scores_codex":[0.9999745,0.000003381647,0.000001342846,0.000006620078,0.000006161835,0.000007957718],"domain_scores_gemma":[0.9999679,0.000009155411,0.000008170575,0.000003515521,0.000004346997,0.000006852268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001037133,0.00004688968,0.002187426,0.0001139201,0.000009169472,0.000441781,0.0000652516,0.003906013,0.983916,0.004017195,0.0001322865,0.005060321],"study_design_scores_gemma":[0.00008184554,0.0007032677,0.06126965,0.00009162535,0.00009595983,0.002740511,0.0006883426,0.1342327,0.7647865,0.022142,0.01312081,0.00004676089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909158,0.002602756,0.004247869,0.0004389434,0.00001228597,0.00001343404,0.00006038393,0.00003572399,0.001672654],"genre_scores_gemma":[0.9944556,0.0017319,0.003152682,0.0001069253,0.00001449053,0.000009492739,0.0001169417,0.000005415489,0.0004064946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978291,"threshold_uncertainty_score":0.003933549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07703213694441814,"score_gpt":0.3116022633024973,"score_spread":0.2345701263580792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}