{"id":"W3004340040","doi":"10.4049/jimmunol.1900774","title":"Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; U.S. Food and Drug Administration; University of Melbourne; National Health and Medical Research Council; European Commission; Clifford Craig Foundation","keywords":"Immunology; Biology; T-cell receptor; CD8; Chemokine; Immunosenescence; Immune system; Cytokine; Young adult; Inflammation; Ex vivo; T cell; In vivo; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007600928,0.0002140929,0.0004934981,0.0002241255,0.0002255307,0.00002362047,0.0004306312,0.0002742196,0.0005554261],"category_scores_gemma":[0.0001748858,0.0001389717,0.0001147227,0.0002417469,0.0002332765,0.000189935,0.0001073389,0.001099805,0.0001990748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008568702,"about_ca_system_score_gemma":0.0001273077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001236361,"about_ca_topic_score_gemma":0.00004817985,"domain_scores_codex":[0.9973659,0.00132052,0.0007379842,0.000158696,0.00006098667,0.0003559028],"domain_scores_gemma":[0.9985794,0.0002750702,0.0007587919,0.0001982076,0.0001654563,0.00002311875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003486009,0.0003000169,0.001387928,0.000006296586,0.0005970676,0.00002874703,0.002940251,0.00008393876,0.9837902,0.00007638674,0.00706379,0.0002394012],"study_design_scores_gemma":[0.0118528,0.004181571,0.1998014,0.0002337422,0.0003412671,0.001552582,0.002909135,0.000008134249,0.7672493,0.00003735051,0.01139292,0.0004398077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993628,0.001002589,0.0001416319,0.003513369,0.001324127,0.0002017254,0.00000750648,0.00002470433,0.0001563062],"genre_scores_gemma":[0.9975657,0.0002446208,0.00002172442,0.00120278,0.00004454378,0.000002747332,0.0000232959,0.0000232158,0.0008713723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165409,"threshold_uncertainty_score":0.6081527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373487627675725,"score_gpt":0.2329563999001355,"score_spread":0.2192215236233782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}