{"id":"W3004442100","doi":"10.1038/s41467-019-14052-x","title":"Divergent mutational processes distinguish hypoxic and normoxic tumours","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Prostate Cancer Canada; Simon Fraser University; University of Ottawa; McGill University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; McGill University and Génome Québec Innovation Centre; Toronto General Hospital; University of Toronto; University Health Network; Genome Canada; Canada's Michael Smith Genome Sciences Centre; Vector Institute; Institute of Cancer Research; Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Government of Ontario; Prostate Cancer Canada; Genome Canada; Francis Crick Institute; Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Ontario Genomics; Cancer Research UK; Government of Canada; Ontario Institute for Cancer Research; Ontario Genomics Institute; Movember Foundation","keywords":"PTEN; Biology; Hypoxia (environmental); Gene; Cancer research; Genetics; Genome; Tumour heterogeneity; Cancer; Computational biology; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005366448,0.00009945566,0.00009230517,0.00001805231,0.0001991642,0.0000264443,0.0004176315,0.0001312873,0.000009396823],"category_scores_gemma":[0.0006567739,0.00009901184,0.00003665401,0.0001515004,0.0001156524,0.000004742812,0.0003191743,0.0002356612,0.000004978061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005749243,"about_ca_system_score_gemma":0.0001292918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006973336,"about_ca_topic_score_gemma":0.0001670024,"domain_scores_codex":[0.9994265,0.00003809779,0.000121025,0.0002008829,0.00009911568,0.0001143425],"domain_scores_gemma":[0.9991882,0.00003156197,0.0000633381,0.0004240931,0.0001847409,0.0001080997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003568018,0.0008923938,0.0606033,0.0005190396,0.0005470131,0.000004700876,0.004311853,0.0001644187,0.5698221,0.01878398,0.3114523,0.03254213],"study_design_scores_gemma":[0.000456853,0.00006245387,0.03217703,0.00001129826,0.00005560361,0.00001663156,0.0001531312,0.0000873012,0.008329838,0.0001441442,0.9582806,0.0002251728],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6892073,0.2750941,0.0006798035,0.02420106,0.001056042,0.0006862433,0.0004772883,0.0001164068,0.008481789],"genre_scores_gemma":[0.9900511,0.005014761,0.002005622,0.001682133,0.0006378379,0.00003348184,0.0004502222,0.00001363645,0.0001112045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6468283,"threshold_uncertainty_score":0.4037586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820719906400344,"score_gpt":0.2795784416476425,"score_spread":0.2613712425836391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}