{"id":"W3004498009","doi":"10.1038/s41586-020-1970-0","title":"Genomic basis for RNA alterations in cancer","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":423,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; BC Cancer Agency; University of British Columbia; Prostate Cancer Canada; Université de Montréal; Hospital for Sick Children; Simon Fraser University; University of Ottawa; McGill University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; Vector Institute; McGill University and Génome Québec Innovation Centre; Toronto General Hospital; University of Toronto; University Health Network; Genome Canada; Canada's Michael Smith Genome Sciences Centre; Institute of Cancer Research; Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; Medical Research Council; European Commission; Francis Crick Institute","keywords":"RNA; Biology; Genetics; Computational biology; Cancer; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287201,0.0001687549,0.0002219598,0.001014305,0.0002125164,0.0003204849,0.0001625494,0.0002654395,0.001767943],"category_scores_gemma":[0.0004880518,0.000101269,0.0002298244,0.000971615,0.0002450609,0.0001459235,0.0002789026,0.0002265253,0.0003176568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001886616,"about_ca_system_score_gemma":0.0001114806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000453065,"about_ca_topic_score_gemma":0.0005969375,"domain_scores_codex":[0.9997956,0.00001942594,0.00001669962,0.00008907718,0.00004619875,0.00003297227],"domain_scores_gemma":[0.9995764,0.0001110364,0.0001868887,0.0000422951,0.00004300124,0.00004041327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005816685,0.00004410458,0.2695247,0.0002494292,0.0002868771,0.00225317,0.0001216203,0.00117643,0.7007914,0.0005472463,0.0006137099,0.02380964],"study_design_scores_gemma":[0.00001403613,0.0001252159,0.9475504,0.00001932349,0.0001498277,0.005285641,0.00007283031,0.001872292,0.04038073,0.0009006372,0.003614781,0.00001431428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917181,0.002604974,0.002195148,0.00008320654,0.00001832738,0.00001527465,0.002329627,0.0001054003,0.0009299648],"genre_scores_gemma":[0.996933,0.0003840175,0.0007083109,0.00005042448,0.00001721605,0.00001197861,0.001595122,0.00001088849,0.0002890757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001767943,"threshold_uncertainty_score":0.00591433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483784036505889,"score_gpt":0.2928755257961292,"score_spread":0.2780376854310704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}