{"id":"W3004509744","doi":"10.1007/s00216-020-02398-x","title":"Comparison of N-ethyl maleimide and N-(1-phenylethyl) maleimide for derivatization of biological thiols using liquid chromatography-mass spectrometry","year":2020,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Concordia University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Derivatization; Maleimide; Chemistry; Thiol; Chromatography; Glutathione; Reagent; Cysteine; Mass spectrometry; High-performance liquid chromatography; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953482,0.0002725175,0.0006941695,0.00004528918,0.00005776726,0.00001588203,0.0002162942,0.0004422322,0.00004454706],"category_scores_gemma":[0.0007826096,0.000229787,0.0002132569,0.0003018759,0.0009593175,0.000006247043,0.0002047848,0.0001649616,3.765606e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009532038,"about_ca_system_score_gemma":0.00004994385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004971323,"about_ca_topic_score_gemma":5.997393e-7,"domain_scores_codex":[0.9981683,0.00004976225,0.0006774016,0.0006103168,0.0001591497,0.0003350374],"domain_scores_gemma":[0.9989207,0.0001960363,0.0002194548,0.0002394786,0.0001631779,0.0002611018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005464201,0.00009564899,0.05065333,0.0002775372,0.0002287286,0.000001700499,0.00001472221,0.00001499427,0.9474869,0.0005251536,0.00004786373,0.0001070415],"study_design_scores_gemma":[0.0007085687,0.001072061,0.00222217,0.00003464734,0.0002145192,0.00001967264,0.0001764993,0.01695452,0.9774949,0.0003851857,0.0003939545,0.0003233052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799819,0.001100571,0.01777161,0.0005124119,0.00001849562,0.000166186,0.00006371154,0.00001421572,0.0003708733],"genre_scores_gemma":[0.9887232,0.0001947114,0.01054903,0.0002113778,0.0001896897,0.000005023113,0.00009797463,0.000018185,0.00001080122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04843115,"threshold_uncertainty_score":0.9370443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05508334904446045,"score_gpt":0.3215731870349945,"score_spread":0.2664898379905341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}