{"id":"W3004584919","doi":"10.1038/s41598-020-58644-w","title":"Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Canadian Association of Gastroenterology; Government of Canada; London Health Sciences Centre","keywords":"Pregnane X receptor; Farnesoid X receptor; Bile acid; Chenodeoxycholic acid; Internal medicine; Taurocholic acid; Glycocholic acid; Lithocholic acid; FGF19; Chemistry; Enterohepatic circulation; Endocrinology; In vivo; CYP3A4; Cholesterol 7 alpha-hydroxylase; G protein-coupled bile acid receptor; Cholic acid; Receptor; Nuclear receptor; Biochemistry; Biology; Cytochrome P450; Medicine; Metabolism; Fibroblast growth factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519772,0.000243994,0.0005916841,0.0004988548,0.0004201915,0.0004118135,0.0001193713,0.0003586202,0.0009940465],"category_scores_gemma":[0.0009778878,0.0002273848,0.000234392,0.0004721367,0.000245779,0.0002412084,0.0002032097,0.0003916981,0.0001184588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221737,"about_ca_system_score_gemma":0.0001441029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006565,"about_ca_topic_score_gemma":0.001169613,"domain_scores_codex":[0.9997848,0.00006402418,0.00003014216,0.00005805262,0.00003318757,0.00002991147],"domain_scores_gemma":[0.9996107,0.00009039112,0.0001512152,0.00002268251,0.00004284667,0.00008211256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002912404,0.0001892677,0.9767752,0.00007455843,0.0001040249,0.001016779,0.0002742039,0.00008741379,0.008896505,0.00003967861,0.0001260734,0.009503798],"study_design_scores_gemma":[0.00003580337,0.0008310443,0.9962119,0.000008783044,0.00006629799,0.001609617,0.0001559014,0.0001088781,0.0006206572,0.00003028525,0.0003170359,0.000003809536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990055,0.0006371198,0.00006254943,0.00002814805,0.000004120793,0.000003272911,0.00003442481,0.000003282389,0.0002216428],"genre_scores_gemma":[0.9995407,0.0001674487,0.00009998017,0.00001794256,0.000005187494,0.000003150211,0.00005880161,8.533923e-7,0.0001059081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006565,"threshold_uncertainty_score":0.003325462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00867067772060471,"score_gpt":0.2085714830420183,"score_spread":0.1999008053214136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}