{"id":"W3004589099","doi":"10.2337/db19-0764","title":"L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk Fonden; Copenhagen Graduate School for Nanoscience and Nanotechnology; École Polytechnique Fédérale de Lausanne; Medical Research Council; Novo Nordisk; Steno Diabetes Center Copenhagen; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Paracrine signalling; Incretin; Cell biology; Biology; Receptor; Endocrinology; Internal medicine; G protein-coupled bile acid receptor; Lithocholic acid; Bile acid; Biochemistry; Type 2 diabetes; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005635611,0.0001604999,0.0003037035,0.00002823356,0.00007008381,0.00004225735,0.00003053926,0.00008121684,0.0002333885],"category_scores_gemma":[0.0001202001,0.0001349918,0.00003252742,0.0001545923,0.00004183943,0.0001244698,0.00003964156,0.0001232732,0.00003073273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001078878,"about_ca_system_score_gemma":0.00001676546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008942177,"about_ca_topic_score_gemma":5.662331e-8,"domain_scores_codex":[0.9991422,0.00003005228,0.000182686,0.0002856252,0.0001475369,0.0002119573],"domain_scores_gemma":[0.9994932,0.0001057835,0.00006143723,0.0001093409,0.00004861839,0.0001816551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002373523,0.00005207653,0.198144,0.0001784871,0.00004759405,8.177826e-7,0.0007635891,2.241493e-7,0.7956828,0.0000194068,0.004071198,0.001016054],"study_design_scores_gemma":[0.002061122,0.0004569415,0.01921767,0.00006376335,0.0001466933,5.0453e-7,0.000215093,0.001873096,0.9714009,0.000134728,0.004246397,0.0001831392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943964,0.001965298,0.00004134306,0.002301129,0.00004646323,0.0002784563,0.0000240068,0.00008238784,0.0008644456],"genre_scores_gemma":[0.9938967,0.000133218,0.0003478241,0.005209201,0.00009395675,0.00003313267,0.00007964351,0.0000198998,0.0001864681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1789263,"threshold_uncertainty_score":0.5504807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176316310755784,"score_gpt":0.2419181331115118,"score_spread":0.220154970003954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}