{"id":"W3004589099","doi":"10.2337/db19-0764","title":"L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk Fonden; Copenhagen Graduate School for Nanoscience and Nanotechnology; École Polytechnique Fédérale de Lausanne; Medical Research Council; Novo Nordisk; Steno Diabetes Center Copenhagen; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Paracrine signalling; Incretin; Cell biology; Biology; Receptor; Endocrinology; Internal medicine; G protein-coupled bile acid receptor; Lithocholic acid; Bile acid; Biochemistry; Type 2 diabetes; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009925461,0.0002323417,0.0002222934,0.0001869122,0.0001426168,0.0003001281,0.000133505,0.0002077327,0.001038898],"category_scores_gemma":[0.00006791161,0.0001102972,0.0002371292,0.0001302553,0.0002154057,0.000175768,0.0002936479,0.000480775,0.0004632962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688822,"about_ca_system_score_gemma":0.0001905941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599643,"about_ca_topic_score_gemma":0.001104691,"domain_scores_codex":[0.9999077,0.0000165307,0.000009538713,0.00001910272,0.00001969712,0.00002739781],"domain_scores_gemma":[0.999916,0.000008338206,0.00002401915,0.000008497833,0.00001072972,0.00003236612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001621785,0.00001420327,0.0002727061,0.0000384224,0.000002670423,0.00009624522,0.00002202776,0.00001817046,0.9970131,0.0001019913,0.00004128531,0.002216995],"study_design_scores_gemma":[0.00003664793,0.0003729203,0.009203752,0.00001866456,0.00001946869,0.0004051824,0.00009319935,0.0004086224,0.9840325,0.0000777521,0.005325192,0.000006181985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891188,0.004290727,0.002696645,0.0002528929,0.00003818815,0.00002449179,0.000294351,0.0001337744,0.00315016],"genre_scores_gemma":[0.9937063,0.001724509,0.001899282,0.0001231683,0.00001221871,0.00001939943,0.0002791006,0.00001524166,0.002220824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038898,"threshold_uncertainty_score":0.003475487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176316310755784,"score_gpt":0.2419181331115118,"score_spread":0.220154970003954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}