{"id":"W3004637332","doi":"10.1186/s13058-020-1247-4","title":"Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers","year":2020,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Université Laval; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier universitaire de Québec; University of Toronto","funders":"National Cancer Institute; Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; Medical Research Council; Centre Léon Bérard; Centro de Investigación Biomédica en Red de Cáncer; Institut Claudius Regaud; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Institut National Du Cancer; Newcastle upon Tyne Hospitals NHS Foundation Trust; Hungarian Scientific Research Fund; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation de France; Great Ormond Street Hospital for Children; Trinity College Dublin; Canadian Institutes of Health Research; Cancerfonden; National Breast Cancer Foundation; Ministerstvo Školství, Mládeže a Tělovýchovy; Central Manchester University Hospitals NHS Foundation Trust; University of Nottingham; Cancer Australia; University of Aberdeen; Institut Bergonié; Deutsche Krebshilfe; University of Glasgow; European Commission; Fondation du cancer du sein du Québec; KWF Kankerbestrijding; Nottingham University Hospitals NHS Trust; University of Southampton; Cancer Research UK; Norway Grants; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Government of Canada; Lunds Universitet; University Hospitals of Leicester NHS Trust; Royal Marsden NHS Foundation Trust; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; Genome Canada","keywords":"Medicine; Breast cancer; Surgical oncology; Prospective cohort study; Oncology; Menopause; Gynecology; Oophorectomy; Internal medicine; Cancer; General surgery; Surgery; Hysterectomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005354129,0.0001946514,0.0002115284,0.0001244441,0.0002437215,0.00008613139,0.0002753393,0.0001285598,0.0001022562],"category_scores_gemma":[0.0001474517,0.0001933607,0.00003755332,0.0003501689,0.0004600159,0.00004218369,0.0002448305,0.0004445064,0.000001254874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003449888,"about_ca_system_score_gemma":0.0007071474,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00971225,"about_ca_topic_score_gemma":0.001274611,"domain_scores_codex":[0.9978308,0.0002477866,0.0002610072,0.0007955904,0.0005128758,0.00035192],"domain_scores_gemma":[0.9984627,0.00003622792,0.0001767526,0.0002567123,0.0008371037,0.0002305155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001399779,0.00005408594,0.7630959,0.00008219007,0.0007256717,0.000006095367,0.002816592,0.0009580805,0.1782459,0.00004560565,0.0007322885,0.05183781],"study_design_scores_gemma":[0.001281412,0.000180717,0.9515982,0.00005477604,0.00006840046,0.0001110293,0.0008424147,0.002239532,0.0427893,0.00006499025,0.0005130616,0.0002561343],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929825,0.002634008,0.00005497196,0.001410748,0.0002284738,0.0005563981,0.001929809,0.00001740792,0.0001856793],"genre_scores_gemma":[0.9949662,0.003504706,0.0002817746,0.00007711426,0.0007062095,0.0002749932,0.00009387869,0.00004527902,0.00004984512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1885024,"threshold_uncertainty_score":0.9968821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535609044721028,"score_gpt":0.339720943349213,"score_spread":0.3243648529020027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}