{"id":"W3004637332","doi":"10.1186/s13058-020-1247-4","title":"Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers","year":2020,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Université Laval; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier universitaire de Québec; University of Toronto","funders":"National Cancer Institute; Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; Medical Research Council; Centre Léon Bérard; Centro de Investigación Biomédica en Red de Cáncer; Institut Claudius Regaud; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Institut National Du Cancer; Newcastle upon Tyne Hospitals NHS Foundation Trust; Hungarian Scientific Research Fund; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation de France; Great Ormond Street Hospital for Children; Trinity College Dublin; Canadian Institutes of Health Research; Cancerfonden; National Breast Cancer Foundation; Ministerstvo Školství, Mládeže a Tělovýchovy; Central Manchester University Hospitals NHS Foundation Trust; University of Nottingham; Cancer Australia; University of Aberdeen; Institut Bergonié; Deutsche Krebshilfe; University of Glasgow; European Commission; Fondation du cancer du sein du Québec; KWF Kankerbestrijding; Nottingham University Hospitals NHS Trust; University of Southampton; Cancer Research UK; Norway Grants; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Government of Canada; Lunds Universitet; University Hospitals of Leicester NHS Trust; Royal Marsden NHS Foundation Trust; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; Genome Canada","keywords":"Medicine; Breast cancer; Surgical oncology; Prospective cohort study; Oncology; Menopause; Gynecology; Oophorectomy; Internal medicine; Cancer; General surgery; Surgery; Hysterectomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001324802,0.0003876729,0.000389543,0.0006746767,0.0005286567,0.0007662359,0.0004862948,0.0005908543,0.001247913],"category_scores_gemma":[0.002430445,0.0005424835,0.000948346,0.001010102,0.0003585556,0.0004665373,0.0005689296,0.000759596,0.0001775437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613059,"about_ca_system_score_gemma":0.0004230266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01322769,"about_ca_topic_score_gemma":0.01001036,"domain_scores_codex":[0.9995888,0.0001023083,0.00003463386,0.0001443167,0.00005304534,0.00007689347],"domain_scores_gemma":[0.9984691,0.0002343612,0.0005837978,0.0002712148,0.0001165756,0.0003250102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004391607,0.00003476896,0.9985231,0.00000660629,0.000119188,0.00004231997,0.00006500084,0.0000311884,0.0001288696,0.000009177421,0.00004500901,0.0005557717],"study_design_scores_gemma":[0.00002602859,0.0001717842,0.9990966,0.000006997152,0.0001038814,0.0002368397,0.0000963581,0.00009905918,0.00003812605,0.00001427251,0.0001053738,0.000004621806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991352,0.0003465613,0.00006333469,0.0000203688,0.000004281854,0.000006336498,0.0003217168,0.000001652735,0.0001005213],"genre_scores_gemma":[0.9988457,0.0002467093,0.0001200081,0.00001965182,0.000007077288,0.00001018073,0.0006256311,0.000002240518,0.0001228861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01322769,"threshold_uncertainty_score":0.02630144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535609044721028,"score_gpt":0.339720943349213,"score_spread":0.3243648529020027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}