{"id":"W3004655368","doi":"10.1016/j.cmet.2020.01.006","title":"Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming","year":2020,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":347,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada; Terry Fox Research Institute; Canada Foundation for Innovation","keywords":"Methionine; H3K4me3; Epigenetics; Reprogramming; Biology; Cell biology; DNA methylation; Histone methylation; Histone; Methylation; Chromatin; Gene expression; Cell; Biochemistry; Promoter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811868,0.0002402323,0.0002407202,0.0002195164,0.0002039173,0.0007538293,0.0002090752,0.0003633106,0.00204148],"category_scores_gemma":[0.0002139534,0.000177634,0.0001777206,0.000130696,0.0002619427,0.0003866905,0.0003644154,0.0004948206,0.0004942455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421319,"about_ca_system_score_gemma":0.0002168763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000422497,"about_ca_topic_score_gemma":0.001143617,"domain_scores_codex":[0.9998161,0.00004020619,0.000009490341,0.00005279403,0.00003149831,0.00004990122],"domain_scores_gemma":[0.9998726,0.00002101927,0.00003088187,0.00001367051,0.00002281203,0.00003913488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002300577,0.000008737205,0.0009024671,0.00001960664,0.000005237169,0.00004573434,0.00002434722,0.00005463463,0.9962226,0.0003299502,0.00005427055,0.002102329],"study_design_scores_gemma":[0.00004261599,0.0003840798,0.03672063,0.00002284409,0.00004448141,0.0002671385,0.0003233932,0.001946748,0.9524675,0.001311854,0.006449239,0.00001956009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848678,0.00388034,0.004317878,0.0005403396,0.0001109928,0.00001888565,0.0003916946,0.0001271995,0.005744997],"genre_scores_gemma":[0.995756,0.0006413213,0.001121806,0.00007012166,0.00002137648,0.000008456726,0.0001375991,0.00002247158,0.002220863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204148,"threshold_uncertainty_score":0.006829441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328532175656186,"score_gpt":0.2615850754219668,"score_spread":0.2382997536654049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}