{"id":"W3004655368","doi":"10.1016/j.cmet.2020.01.006","title":"Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming","year":2020,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":347,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada; Terry Fox Research Institute; Canada Foundation for Innovation","keywords":"Methionine; H3K4me3; Epigenetics; Reprogramming; Biology; Cell biology; DNA methylation; Histone methylation; Histone; Methylation; Chromatin; Gene expression; Cell; Biochemistry; Promoter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004444454,0.0002940967,0.0004318578,0.00006575647,0.0001083313,0.00003624324,0.0002903657,0.000266079,0.0000994626],"category_scores_gemma":[0.0002819589,0.0002848654,0.0002449714,0.0003212251,0.0001133728,0.00001440486,0.0001684917,0.0001499395,0.0000230787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005404574,"about_ca_system_score_gemma":0.00008845136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003057678,"about_ca_topic_score_gemma":0.000003200364,"domain_scores_codex":[0.9977562,0.0003117804,0.0005983866,0.0006722008,0.0003228788,0.0003385132],"domain_scores_gemma":[0.9987108,0.00005089702,0.000352482,0.0004780751,0.0002510653,0.0001566881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001472454,0.00007385611,0.0002039837,0.00006731743,0.00003542446,0.000001054977,0.0005594797,0.0006076075,0.9938833,0.0002157244,0.0001547787,0.004050241],"study_design_scores_gemma":[0.0006460409,0.0001135289,0.006152187,0.000005933113,0.0001288996,5.877588e-7,0.00009885594,0.0001672466,0.8153904,0.000459877,0.1765853,0.0002510996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9027179,0.06488519,0.02832542,0.0004602194,0.0002845665,0.0004139583,0.00003090459,0.00003769872,0.002844158],"genre_scores_gemma":[0.9681947,0.002943011,0.02668511,0.0003046129,0.0006389577,0.00002798263,0.000105294,0.00006215423,0.001038146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1784929,"threshold_uncertainty_score":0.9999604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328532175656186,"score_gpt":0.2615850754219668,"score_spread":0.2382997536654049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}