{"id":"W3004666955","doi":"10.1113/jp279307","title":"Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca<sup>2+</sup> binding and cause misfolding","year":2020,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Research Council Canada; Novo Nordisk Fonden; Western Economic Diversification Canada; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden; Aalborg Universitet; Danmarks Frie Forskningsfond; Canadian Light Source","keywords":"Calmodulin; Ryanodine receptor; Cooperativity; Mutant; Mutation; EF hand; Voltage-dependent calcium channel; Binding domain; Chemistry; Binding site; Calcium channel; Biophysics; Biology; Calcium; Cell biology; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007553888,0.0004798913,0.0002145575,0.0001662254,0.000186137,0.000162413,0.0002261759,0.0004358418,0.001702398],"category_scores_gemma":[0.0002175137,0.0001213015,0.0002681738,0.0001010281,0.0002933905,0.0001054302,0.0002287674,0.0004744082,0.0003183435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601024,"about_ca_system_score_gemma":0.0001126483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006987469,"about_ca_topic_score_gemma":0.001086124,"domain_scores_codex":[0.9998633,0.00002273294,0.00001457591,0.00002432593,0.00005669277,0.00001840443],"domain_scores_gemma":[0.9998564,0.00003963495,0.00004952158,0.000008980462,0.000008844319,0.00003668348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005278771,0.00001999024,0.0004610278,0.00001687303,0.000007869003,0.0005255378,0.00001260645,0.00007763761,0.9977039,0.0001012743,0.00008586008,0.0009347819],"study_design_scores_gemma":[0.000116716,0.0004928234,0.03201158,0.00002004886,0.00004041778,0.006688076,0.00003708222,0.003484724,0.952598,0.0002742481,0.004217968,0.00001837265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958669,0.0003910497,0.001987858,0.0001033618,0.00004957289,0.00003568304,0.0001932586,0.00007819875,0.001294139],"genre_scores_gemma":[0.9969388,0.0001460807,0.001757607,0.00009367765,0.00001562012,0.00001831652,0.000224763,0.0000324287,0.0007728636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702398,"threshold_uncertainty_score":0.005695105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880231197030919,"score_gpt":0.2759555788048971,"score_spread":0.2571532668345879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}