{"id":"W3004761768","doi":"10.1038/s41388-020-1188-5","title":"mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake","year":2020,"lang":"en","type":"article","venue":"Oncogene","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Novartis Pharma; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Alberta Cancer Foundation","keywords":"Biology; MPTP; Mitochondrion; Mitochondrial permeability transition pore; Cyclin-dependent kinase 5; Internal medicine; Apoptosis; Cell biology; Endocrinology; Genetics; Dopamine; Programmed cell death; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358483,0.0003934756,0.0002791582,0.0003338725,0.0002224286,0.0003596739,0.0003045688,0.000301056,0.001807957],"category_scores_gemma":[0.0001864628,0.000150697,0.0003108579,0.0001755238,0.0003243035,0.0003516843,0.0002684542,0.000657764,0.0004444418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005862391,"about_ca_system_score_gemma":0.0002004553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001259862,"about_ca_topic_score_gemma":0.0009771601,"domain_scores_codex":[0.9998524,0.0000154902,0.00002219635,0.00003696847,0.00004024134,0.00003269112],"domain_scores_gemma":[0.9998349,0.00002564173,0.00005708715,0.00002064685,0.00001423234,0.00004752697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000989503,0.00001219627,0.0003318593,0.00003990461,0.000009970569,0.0001574597,0.000007706775,0.000047933,0.998623,0.0001121703,0.00004506068,0.0005137635],"study_design_scores_gemma":[0.000009015179,0.00005636191,0.006079854,0.00000530591,0.00001602665,0.0005112905,0.00002141617,0.000429514,0.9910899,0.00005037997,0.001727482,0.000003384625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888625,0.003758375,0.004408643,0.0002158054,0.00007117496,0.00002453874,0.0009432825,0.0001308234,0.001584955],"genre_scores_gemma":[0.9967915,0.0006044335,0.0009266053,0.00004811533,0.00000610664,0.00001600969,0.0004422676,0.00001608345,0.001148773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807957,"threshold_uncertainty_score":0.006048203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756613244451193,"score_gpt":0.2550530066171926,"score_spread":0.2374868741726807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}