{"id":"W3004761768","doi":"10.1038/s41388-020-1188-5","title":"mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake","year":2020,"lang":"en","type":"article","venue":"Oncogene","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Novartis Pharma; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Alberta Cancer Foundation","keywords":"Biology; MPTP; Mitochondrion; Mitochondrial permeability transition pore; Cyclin-dependent kinase 5; Internal medicine; Apoptosis; Cell biology; Endocrinology; Genetics; Dopamine; Programmed cell death; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008188035,0.000238218,0.0002859002,0.00003206215,0.0001109427,0.00003973007,0.0002862003,0.0002647923,0.000790937],"category_scores_gemma":[0.0002180431,0.0002438125,0.0001294298,0.0001763293,0.00004147251,0.000004372585,0.0001698714,0.000128029,0.0004569374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001759011,"about_ca_system_score_gemma":0.0001249585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000942788,"about_ca_topic_score_gemma":0.0000693827,"domain_scores_codex":[0.9984239,0.0001060372,0.0002983448,0.0006581129,0.0001691261,0.0003444896],"domain_scores_gemma":[0.9990013,0.0000137637,0.00007838287,0.0003776362,0.00008690562,0.0004420373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003520346,0.00002699783,0.0001503506,0.000006334653,0.00003895942,0.00004430921,0.0001337305,0.00001677817,0.8006003,0.000009529721,0.1978056,0.0008150194],"study_design_scores_gemma":[0.0009706559,0.0003789434,0.00004309495,0.000003769268,0.00001984137,0.00002352295,0.00002678339,0.00002333655,0.4924236,0.000003630264,0.5058888,0.0001941041],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973523,0.0004831956,0.01559048,0.004185404,0.001520214,0.0005899019,0.0004003788,0.00005880531,0.003648624],"genre_scores_gemma":[0.9145038,0.0001229661,0.009780095,0.0584459,0.007155513,0.00016698,0.001673055,0.0001632125,0.007988546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3081768,"threshold_uncertainty_score":0.9942384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756613244451193,"score_gpt":0.2550530066171926,"score_spread":0.2374868741726807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}