{"id":"W3004779610","doi":"10.1186/s13075-020-2099-0","title":"Safety results of ixekizumab with 1822.2 patient-years of exposure: an integrated analysis of 3 clinical trials in adult patients with psoriatic arthritis","year":2020,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Mitsubishi Tanabe Pharma Corporation; Astellas Pharma; Eisai; Mylan; Chugai Pharmaceutical; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Psoriatic arthritis; Ixekizumab; Adverse effect; Internal medicine; Population; Clinical trial; Incidence (geometry); Arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.02984652,0.0007661569,0.003397248,0.0008626152,0.0002640273,0.001807858,0.0005426989,0.0009795649,0.001172022],"category_scores_gemma":[0.01723455,0.0004402742,0.005934132,0.001731558,0.0004801888,0.0009345244,0.0008436703,0.001262755,0.0001571147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009788293,"about_ca_system_score_gemma":0.001362833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005401457,"about_ca_topic_score_gemma":0.0006604528,"domain_scores_codex":[0.983771,0.009827464,0.001981954,0.001939056,0.002028369,0.000452183],"domain_scores_gemma":[0.9785402,0.008971807,0.008659254,0.001630042,0.001266108,0.0009326654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4373952,0.002430803,0.3335308,0.006274868,0.06867178,0.0003250978,0.0003911584,0.008250603,0.007785249,0.0002371304,0.00159544,0.1331117],"study_design_scores_gemma":[0.07735541,0.11003,0.7445224,0.0005629545,0.05147567,0.001103331,0.0001576526,0.005144692,0.003703481,0.0004592403,0.005343296,0.0001419852],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654549,0.02846788,0.001709211,0.0001617812,0.00002849476,0.0008416667,0.002387518,0.00006036375,0.0008881425],"genre_scores_gemma":[0.9920599,0.00265802,0.001245323,0.0001756396,0.00005874364,0.0005018305,0.003111776,0.00001700555,0.000171653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9966028,"threshold_uncertainty_score":0.1578454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0918443257871289,"score_gpt":0.4001813519009092,"score_spread":0.3083370261137803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}