{"id":"W3004794108","doi":"10.1016/j.bpj.2019.11.736","title":"Exploring the Role of the First Extracellular Loop of CaV2.3 in Mediating the Interaction with Auxiliary Subunits","year":2020,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Protein subunit; Extracellular; Voltage-dependent calcium channel; Depolarization; Homology modeling; Cav1.2; Biophysics; Chemistry; Alanine; Biology; Gene; Calcium; Biochemistry; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003982617,0.0003230984,0.0002678567,0.0001026426,0.0004248544,0.0007093414,0.0007439906,0.0006333813,0.001606913],"category_scores_gemma":[0.0005180449,0.0001323705,0.0002875877,0.00009581391,0.0004414023,0.0009602243,0.0002665071,0.0007678208,0.0005006175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006175019,"about_ca_system_score_gemma":0.0004767719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300279,"about_ca_topic_score_gemma":0.001052414,"domain_scores_codex":[0.9998376,0.00002937824,0.000008127702,0.00002957973,0.00003263715,0.00006260082],"domain_scores_gemma":[0.9998086,0.00008630024,0.00002781018,0.00001545423,0.00002398977,0.00003790085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009111361,0.00009065535,0.0008989301,0.0000640862,0.000008705848,0.0003820562,0.00009309958,0.0006586207,0.9916726,0.00227257,0.0001172572,0.002830263],"study_design_scores_gemma":[0.00007960662,0.0002025113,0.005710246,0.00002281403,0.00002915455,0.0006901239,0.0001923617,0.017915,0.9713823,0.001023781,0.002733846,0.00001829062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917459,0.0007979902,0.005107948,0.0003581487,0.00003342913,0.00001591059,0.00005685706,0.00002928677,0.001854648],"genre_scores_gemma":[0.9970443,0.0002679474,0.001586315,0.00009074,0.000009561846,0.000008587614,0.00006878492,0.00000890393,0.000914957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606913,"threshold_uncertainty_score":0.005375683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190007652949311,"score_gpt":0.2224920385006193,"score_spread":0.1905919619711262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}