{"id":"W3004838051","doi":"10.1111/all.14221","title":"Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma","year":2020,"lang":"en","type":"review","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":396,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Sanofi Genzyme; Allergopharma; European Academy of Allergy and Clinical Immunology; Sanofi; Immune Tolerance Network; Regeneron Pharmaceuticals; AstraZeneca; Allergy Therapeutics; Amgen","keywords":"Mepolizumab; Benralizumab; Medicine; Omalizumab; Dupilumab; Internal medicine; Asthma; Pediatrics; Immunology; Immunoglobulin E; Eosinophil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01631653,0.00150367,0.01130887,0.007091729,0.0005422431,0.002447268,0.001212156,0.002117912,0.00264382],"category_scores_gemma":[0.0419807,0.001168929,0.01667076,0.004784052,0.0009430957,0.001687566,0.001175632,0.001566405,0.0001928103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004287231,"about_ca_system_score_gemma":0.006213462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007580821,"about_ca_topic_score_gemma":0.01541354,"domain_scores_codex":[0.9846347,0.006504004,0.005199426,0.0009586309,0.002435951,0.000267229],"domain_scores_gemma":[0.9678781,0.021681,0.007554429,0.0003783018,0.002254593,0.0002535459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001351267,0.00002638435,0.0009938751,0.9168298,0.05396338,0.00005131063,0.00009196362,0.0001146704,0.0002190597,0.0001821613,0.0007466489,0.02542935],"study_design_scores_gemma":[0.002809054,0.0008072664,0.007135157,0.562588,0.4162621,0.0003282238,0.0001681343,0.000239839,0.0003912855,0.0003804356,0.008830752,0.00005972758],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001966676,0.9968224,0.0001134877,0.0002232038,0.0000980352,0.000280873,0.0003196604,0.000005510346,0.0001701621],"genre_scores_gemma":[0.05943543,0.9370863,0.001103872,0.0007397851,0.0001282353,0.0009719884,0.0003814907,0.000007921046,0.0001450291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01631653,"threshold_uncertainty_score":0.08629113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1669695664345194,"score_gpt":0.3749370529018555,"score_spread":0.2079674864673361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}