{"id":"W3004838051","doi":"10.1111/all.14221","title":"Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma","year":2020,"lang":"en","type":"review","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":396,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Sanofi Genzyme; Allergopharma; European Academy of Allergy and Clinical Immunology; Sanofi; Immune Tolerance Network; Regeneron Pharmaceuticals; AstraZeneca; Allergy Therapeutics; Amgen","keywords":"Mepolizumab; Benralizumab; Medicine; Omalizumab; Dupilumab; Internal medicine; Asthma; Pediatrics; Immunology; Immunoglobulin E; Eosinophil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005244778,0.0008606286,0.00473993,0.0001735072,0.000234979,0.00003543949,0.000347135,0.0003629188,0.00006231711],"category_scores_gemma":[0.002962616,0.000338363,0.0007652896,0.0004866979,0.0004040263,0.00006323411,0.0001432934,0.0002271431,0.000002100334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874627,"about_ca_system_score_gemma":0.0004896116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005789345,"about_ca_topic_score_gemma":0.00006548601,"domain_scores_codex":[0.9950733,0.0009239524,0.002470318,0.0008440808,0.0002636161,0.000424778],"domain_scores_gemma":[0.9899604,0.006897648,0.001580023,0.000983083,0.0003752827,0.0002035253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002908582,0.0006209649,0.00000765054,0.4084854,0.003229262,0.00003970806,0.0001382119,0.00001696309,0.000002449298,0.002516941,0.004391703,0.5776422],"study_design_scores_gemma":[0.002855985,0.005721905,0.00003503892,0.2207407,0.001913069,0.000327584,0.00009190089,0.0000622189,0.000001065643,0.00002647242,0.7678766,0.0003475081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002150908,0.9775249,0.00005913644,0.004541176,0.00004830335,0.01613723,0.0014099,0.00003696991,0.00002725192],"genre_scores_gemma":[0.0005332977,0.9936283,0.000728595,0.001009029,0.00009800163,0.003284439,0.0004809182,0.00007425182,0.0001631359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7634849,"threshold_uncertainty_score":0.9999068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1669695664345194,"score_gpt":0.3749370529018555,"score_spread":0.2079674864673361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}