{"id":"W3004867334","doi":"10.1007/s00401-020-02129-7","title":"Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; International Collaboration On Repair Discoveries; University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research; Rosetrees Trust; Wellcome Trust","keywords":"Remyelination; Microglia; Myelin; Scavenger receptor; Phagocytosis; Biology; Progenitor cell; Immunology; CD36; Cell biology; Multiple sclerosis; Receptor; Medicine; Neuroscience; Central nervous system; Stem cell; Endocrinology; Inflammation; Biochemistry; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936317,0.0001733854,0.000245926,0.00006728154,0.0001649077,0.00003199129,0.0004844719,0.00006450954,0.0000300602],"category_scores_gemma":[0.00201915,0.0001272803,0.0001119065,0.0006240123,0.0001151695,0.0001811142,0.000144816,0.0002183255,0.00001969312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001800807,"about_ca_system_score_gemma":0.00003778142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001241382,"about_ca_topic_score_gemma":5.437679e-7,"domain_scores_codex":[0.997439,0.0008152036,0.0006048337,0.0004608678,0.0004513426,0.0002287983],"domain_scores_gemma":[0.9985911,0.0002174871,0.0006865463,0.0003165514,0.0001067504,0.00008153389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003209212,0.00002770523,0.000136797,0.00006742618,7.394988e-7,0.00004212468,0.0003104982,0.0001976003,0.9971453,0.001357441,0.00008510725,0.000597176],"study_design_scores_gemma":[0.0002470489,0.0001524755,0.005024122,0.00002356148,0.00001116171,0.00004676083,0.0000460002,0.005384774,0.9885691,0.00002337747,0.0003715829,0.0001000426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951608,0.00001139418,0.0004855375,0.002637189,0.0005852668,0.0004012922,0.00004154501,0.0001771911,0.0004998386],"genre_scores_gemma":[0.9979444,0.00004991372,0.0001125329,0.001725208,0.00007202147,0.00000792391,0.000003349013,0.00002127236,0.00006337267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008576201,"threshold_uncertainty_score":0.5190341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725654467087491,"score_gpt":0.2256372741371886,"score_spread":0.1983807294663137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}