{"id":"W3004868654","doi":"10.1016/j.bpj.2019.11.2870","title":"Mechanism of Allosteric Inhibition of Plasmodium falciparum CGMP-Dependent Protein Kinase","year":2020,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Molecular spectroscopy and chirality","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Allosteric regulation; Plasmodium falciparum; Protein kinase A; Kinase; Binding site; Chemistry; Protein kinase domain; Biochemistry; Cell biology; Biology; Biophysics; Malaria; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006304009,0.0001393731,0.0002728554,0.00002039604,0.00004535802,0.00002003021,0.0001694214,0.00008826675,0.0003720556],"category_scores_gemma":[0.00002953745,0.000124765,0.0002059064,0.00008977548,0.00005729383,0.0000735586,0.00008357544,0.0003246074,0.00001339499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003019789,"about_ca_system_score_gemma":0.00004988638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006735587,"about_ca_topic_score_gemma":3.162639e-7,"domain_scores_codex":[0.9987884,0.00003820814,0.0003919185,0.0001743051,0.0004165473,0.0001906783],"domain_scores_gemma":[0.9992803,0.000008085398,0.0003144339,0.0001459156,0.00006943192,0.0001817708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002178932,0.0002475731,0.00001132317,0.0001619308,0.00004309268,0.00007161297,0.0001270175,0.000005930618,0.9947125,0.004205518,0.00002158834,0.000174063],"study_design_scores_gemma":[0.000634093,0.0002464892,0.00002175866,0.00008320955,0.0000331888,0.00001923085,0.00005148466,0.0003445448,0.9971511,0.001253301,0.00004449594,0.0001170741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941352,0.00001257368,0.004023355,0.0006075271,0.0000376375,0.00006247695,0.00003958631,0.00001717018,0.001064492],"genre_scores_gemma":[0.9991684,0.000005443464,0.000454278,0.00008702492,0.0002235163,0.000004303148,0.000006815666,0.00001475088,0.00003546696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005033219,"threshold_uncertainty_score":0.5087768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161265621739537,"score_gpt":0.2427641940405586,"score_spread":0.2266376318666049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}