{"id":"W3004888955","doi":"10.1200/jco.2020.38.4_suppl.1","title":"Pembrolizumab for advanced anal squamous cell carcinoma (ASCC): Results from the multicohort, phase II KEYNOTE-158 study.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal and Anal Carcinomas","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Pembrolizumab; Clinical endpoint; Internal medicine; Phases of clinical research; Surgery; Cancer; Oncology; Gastroenterology; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003413102,0.001519479,0.001403994,0.0004226282,0.0004238405,0.0007860624,0.0007211294,0.001022495,0.004212955],"category_scores_gemma":[0.001203046,0.0006090417,0.001002072,0.0004933397,0.000402538,0.0007686521,0.0005973983,0.001454976,0.001148853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007243365,"about_ca_system_score_gemma":0.0009705163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006018314,"about_ca_topic_score_gemma":0.001138081,"domain_scores_codex":[0.9993938,0.0003213585,0.0000511209,0.00009862593,0.00007310507,0.00006193061],"domain_scores_gemma":[0.9993128,0.0001158094,0.0001754298,0.00009594845,0.00007313868,0.0002269213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7416981,0.03897499,0.03752838,0.003471501,0.005469801,0.0004346042,0.0003895031,0.002509322,0.03575342,0.0004317974,0.02006605,0.1132727],"study_design_scores_gemma":[0.6586843,0.2425414,0.06957248,0.0002901875,0.003554863,0.001045363,0.0001320254,0.001350858,0.004248695,0.0003946098,0.01813005,0.00005511569],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97041,0.006428261,0.001276912,0.0004343487,0.0001050901,0.007064552,0.01055928,0.0001652052,0.003556451],"genre_scores_gemma":[0.95807,0.003736793,0.003801457,0.001855069,0.0002017265,0.00720396,0.02126275,0.00007285824,0.003795366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004212955,"threshold_uncertainty_score":0.01805037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1401134497973141,"score_gpt":0.4451741765726717,"score_spread":0.3050607267753576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}