{"id":"W3004897282","doi":"10.1056/nejmoa1803537","title":"Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":861,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto; Hamilton Health Sciences; University of British Columbia; St. Joseph’s Healthcare Hamilton; University of Calgary; Impact; McMaster University; Population Health Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Baxter Healthcare Corporation; Genentech; U.S. Food and Drug Administration; Pfizer; Biogen; InflaRx; Ministry of Health, Labour and Welfare; CSL Behring; National Institute for Health and Care Research; Insmed; Boehringer Ingelheim Japan; Ministère des Affaires Sociales et de la Santé; Health Technology Assessment Programme; Fresenius Medical Care North America; National Health and Medical Research Council; Terumo BCT; AstraZeneca; Barts Charity; Japan Agency for Medical Research and Development; Eli Lilly and Company; Bristol-Myers Squibb; National Center for Research Resources; Asahi Kasei Pharma Corporation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Sanofi; Celgene; GlaxoSmithKline; Amgen; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Vasculitis; ANCA-Associated Vasculitis; Anti-neutrophil cytoplasmic antibody; Medicine; Immunology; Dermatology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001887223,0.0002373223,0.0006187706,0.0001521457,0.0001530375,0.0002316319,0.0001917055,0.0004805617,0.001365886],"category_scores_gemma":[0.002924383,0.00007860682,0.0006507579,0.0001938553,0.0003185652,0.0001590954,0.0001701574,0.0008068986,0.00008759349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561876,"about_ca_system_score_gemma":0.000412857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003772148,"about_ca_topic_score_gemma":0.0008317759,"domain_scores_codex":[0.9984333,0.00122499,0.0000824665,0.00006937981,0.0001272315,0.00006258781],"domain_scores_gemma":[0.9978935,0.001265763,0.0005157495,0.00006826869,0.0000385303,0.0002180926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3288332,0.004094727,0.1273114,0.003903227,0.005962106,0.0008879222,0.0001902644,0.004330814,0.00455975,0.001955192,0.007432106,0.5105393],"study_design_scores_gemma":[0.1581529,0.1811372,0.6104114,0.001627508,0.005924219,0.004720653,0.0002681132,0.006778229,0.003071534,0.006037649,0.02178342,0.00008720745],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362737,0.05805549,0.0006242564,0.002410255,0.0004068969,0.0001179306,0.0001262349,0.00001743095,0.001967757],"genre_scores_gemma":[0.9937738,0.004853529,0.000352806,0.0004066979,0.0003476605,0.00004831714,0.00007188269,0.000001324484,0.000143949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887223,"threshold_uncertainty_score":0.009980679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01926568160786217,"score_gpt":0.2487355479001242,"score_spread":0.2294698662922621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}