{"id":"W3004918388","doi":"10.1111/cts.12737","title":"Once‐Daily Oxycodone Prolonged‐Release Tablets Are Resistant to Alcohol‐Induced Dose Dumping: Results From a Randomized Trial in Healthy Volunteers","year":2020,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada); Therapure Biopharma (Canada); Helix Biopharma (Canada)","funders":"","keywords":"Oxycodone; Alcohol; Crossover study; Pharmacokinetics; Bioavailability; Medicine; Anesthesia; Randomized controlled trial; Absorption (acoustics); Pharmacology; Internal medicine; Placebo; Chemistry; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00267834,0.0009468041,0.002601847,0.0003485265,0.000455832,0.0007620463,0.0007241147,0.001379175,0.004522988],"category_scores_gemma":[0.003135866,0.0007340575,0.001638692,0.0003923354,0.001143208,0.0009828213,0.0003247125,0.001665991,0.0005254188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433862,"about_ca_system_score_gemma":0.0007728405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007471681,"about_ca_topic_score_gemma":0.001570751,"domain_scores_codex":[0.9983504,0.001017405,0.0001473028,0.0001954037,0.0001366847,0.000152912],"domain_scores_gemma":[0.9976908,0.000899538,0.0006152538,0.0001868997,0.0001774748,0.0004301115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9706575,0.008256676,0.0004857776,0.0005203349,0.0008005655,0.00002906753,0.00006275252,0.00007673217,0.004741172,0.00003826116,0.0002059272,0.01412532],"study_design_scores_gemma":[0.7971319,0.196391,0.003930284,0.00003161495,0.0008507171,0.0000387662,0.00004109196,0.0002538106,0.0008938728,0.00004835319,0.0003685109,0.00001988476],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941134,0.002711732,0.0004764677,0.0001782266,0.0002197919,0.001496462,0.0002912183,0.00004957498,0.0004630736],"genre_scores_gemma":[0.9927546,0.002658052,0.001251744,0.000315251,0.0003676719,0.001224687,0.000403534,0.00002415618,0.001000267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004522988,"threshold_uncertainty_score":0.01513088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035654123422246,"score_gpt":0.3841628809555759,"score_spread":0.2805974686133513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}